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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

8 known interactions (drugs) of input target (RAF1): RAF proto-oncogene serine/threonine-protein kinase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB08862 Cholecystokinin Thumb
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
3 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
4 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb
5 Investigational SmallMoleculeDrug DB05190 XL281 Thumb
6 Investigational SmallMoleculeDrug DB05268 iCo-007 Thumb
7 Investigational BiotechDrug DB04973 LErafAON Thumb
8 Approved;
SmallMoleculeDrug DB08912 Dabrafenib Thumb

20 predicted interactions (drugs) of input target (RAF1): RAF proto-oncogene serine/threonine-protein kinase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 40.5%
2 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 38.6%
3 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 37.9%
4 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 36.3%
5 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 35.3%
6 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 33.5%
7 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 31.8%
8 Investigational SmallMoleculeDrug DB05984 RAF-265 Thumb 31.5%
9 Investigational;
SmallMoleculeDrug DB00171 ATP Thumb 31.3%
10 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 30.4%
11 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 30.3%
12 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 29.4%
13 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 28.4%
14 Experimental SmallMoleculeDrug DB07000 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide Thumb 27.3%
15 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 26.8%
16 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 25.2%
17 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 24.5%
18 Experimental SmallMoleculeDrug DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb 24.5%
19 Experimental SmallMoleculeDrug DB06999 N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide Thumb 23.7%
20 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 22.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.