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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9Y663
No. Gene UniProt ID Protein Name Pathway PDB
1 HS3ST3A1 Q9Y663 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 hsa00534 1T8T; 1T8U


5 known interactions (drugs) of input target (HS3ST3A1): Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb
2 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb
3 Experimental SmallMoleculeDrug DB02264 O2-Sulfo-Glucuronic Acid Thumb
4 Experimental SmallMoleculeDrug DB03981 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Thumb
5 Experimental SmallMoleculeDrug DB03959 N,O6-Disulfo-Glucosamine Thumb


20 predicted interactions (drugs) of input target (HS3ST3A1): Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB01109 Heparin Thumb 29.2%
2 Investigational SmallMoleculeDrug DB05434 ABT-510 Thumb 29.1%
3 Experimental SmallMoleculeDrug DB03935 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid Thumb 24.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB01025 Amlexanox Thumb 23.6%
5 Experimental SmallMoleculeDrug DB02098 Adenosine-2'-5'-Diphosphate Thumb 22.8%
6 Approved SmallMoleculeDrug DB00686 Pentosan Polysulfate Thumb 20.7%
7 Experimental SmallMoleculeDrug DB04166 Anthranilic acid Thumb 20.1%
8 Investigational SmallMoleculeDrug DB12307 Foretinib Thumb 20.1%
9 Approved;
Investigational		 SmallMoleculeDrug DB03088 Pidolic Acid Thumb 19.4%
10 Experimental SmallMoleculeDrug DB01901 Sucrosofate Thumb 18.8%
11 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 18.5%
12 Experimental SmallMoleculeDrug DB02337 S-(D-Carboxybutyl)-L-Homocysteine Thumb 18.1%
13 Approved SmallMoleculeDrug DB00364 Sucralfate Thumb 18.1%
14 Approved BiotechDrug DB00071 Insulin Pork Thumb 17.1%
15 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 17.0%
16 Experimental;
Investigational		 SmallMoleculeDrug DB02929 K201 Thumb 16.8%
17 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB01942 Formic Acid Thumb 16.7%
18 Approved;
Investigational		 SmallMoleculeDrug DB00877 Sirolimus Thumb 16.5%
19 Experimental SmallMoleculeDrug DB02497 L-Alpha-Glycerophosphorylserine Thumb 15.6%
20 Experimental SmallMoleculeDrug DB02846 L-thioproline Thumb 15.3%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.