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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q96SW2
No. Gene UniProt ID Protein Name Pathway PDB
1 CRBN Q96SW2 Protein cereblon NA 4M91; 4TZ4

3 known interactions (drugs) of input target (CRBN): Protein cereblon
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB08910 Pomalidomide Thumb
2 Approved;
SmallMoleculeDrug DB01041 Thalidomide Thumb
3 Approved SmallMoleculeDrug DB00480 Lenalidomide Thumb

20 predicted interactions (drugs) of input target (CRBN): Protein cereblon
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb 25.6%
2 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 24.5%
3 Approved;
SmallMoleculeDrug DB13961 Fish oil Thumb 24.2%
4 Investigational SmallMoleculeDrug DB05767 Andrographolide Thumb 23.7%
5 Investigational SmallMoleculeDrug DB05744 CRx-139 Thumb 21.0%
6 Approved SmallMoleculeDrug DB11348 Calcium Phosphate Thumb 20.0%
7 Approved;
SmallMoleculeDrug DB09213 Dexibuprofen Thumb 19.0%
8 Experimental SmallMoleculeDrug DB04137 Guanosine-5'-Triphosphate Thumb 18.7%
9 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb 18.5%
10 Approved;
SmallMoleculeDrug DB01296 Glucosamine Thumb 18.5%
11 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 18.2%
12 Investigational SmallMoleculeDrug DB12140 Dilmapimod Thumb 18.0%
13 Investigational SmallMoleculeDrug DB05095 Cimicoxib Thumb 17.3%
14 Experimental;
SmallMoleculeDrug DB08838 Agmatine Thumb 17.3%
15 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 17.1%
16 Investigational SmallMoleculeDrug DB05207 SD118 Thumb 17.0%
17 Approved SmallMoleculeDrug DB00469 Tenoxicam Thumb 16.7%
18 Approved;
SmallMoleculeDrug DB11582 Thiocolchicoside Thumb 16.5%
19 Investigational BiotechDrug DB05758 CYT007-TNFQb Thumb 16.4%
20 Experimental SmallMoleculeDrug DB01915 S-Hydroxycysteine Thumb 16.3%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.