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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P54760
No. Gene UniProt ID Protein Name Pathway PDB
1 EPHB4 P54760 Ephrin type-B receptor 4 hsa04360 2BBA; 2E7H; 2HLE; 2QKQ; 2VWU; 2VWV; 2VWW; 2VWX; 2VWY; 2VWZ; 2VX0; 2VX1; 2X9F; 2XVD; 2YN8; 3ZEW; 4AW5; 4BB4

11 known interactions (drugs) of input target (EPHB4): Ephrin type-B receptor 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB07251 N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE Thumb
2 Experimental SmallMoleculeDrug DB07249 N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine Thumb
3 Investigational SmallMoleculeDrug DB11973 Tesevatinib Thumb
5 Experimental SmallMoleculeDrug DB07253 N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine Thumb
6 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
7 Experimental SmallMoleculeDrug DB07256 3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE Thumb
8 Experimental SmallMoleculeDrug DB07255 N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE Thumb
9 Experimental SmallMoleculeDrug DB07252 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide Thumb
10 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb
11 Experimental SmallMoleculeDrug DB07250 N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE Thumb

20 predicted interactions (drugs) of input target (EPHB4): Ephrin type-B receptor 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 44.1%
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 40.9%
3 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 40.2%
4 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 34.6%
5 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 31.2%
6 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 28.2%
7 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 26.4%
8 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 26.0%
9 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 24.7%
10 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 24.5%
11 Approved;
SmallMoleculeDrug DB11967 Binimetinib Thumb 24.3%
12 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 24.2%
13 Approved SmallMoleculeDrug DB00364 Sucralfate Thumb 23.7%
14 Approved;
SmallMoleculeDrug DB08875 Cabozantinib Thumb 23.7%
15 Approved;
SmallMoleculeDrug DB01032 Probenecid Thumb 23.6%
16 Experimental SmallMoleculeDrug DB02078 Triglyme Thumb 23.3%
17 Approved;
SmallMoleculeDrug DB08912 Dabrafenib Thumb 23.1%
18 Investigational SmallMoleculeDrug DB05869 Ethyl pyruvate Thumb 22.7%
19 Approved;
SmallMoleculeDrug DB11638 Artenimol Thumb 22.5%
20 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 22.4%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.