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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P48637
No. Gene UniProt ID Protein Name Pathway PDB
1 GSS P48637 Glutathione synthetase hsa00270; hsa00480; hsa01100; hsa04216 2HGS


7 known interactions (drugs) of input target (GSS): Glutathione synthetase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb
2 Experimental SmallMoleculeDrug DB03408 gamma-Glutamylcysteine Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB06151 Acetylcysteine Thumb
5 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb
6 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00143 Glutathione Thumb
7 Approved;
Nutraceutical		 SmallMoleculeDrug DB00151 L-Cysteine Thumb


20 predicted interactions (drugs) of input target (GSS): Glutathione synthetase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 56.9%
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 33.8%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb 27.5%
4 Approved SmallMoleculeDrug DB00454 Pethidine Thumb 26.6%
5 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 25.6%
6 Approved;
Investigational		 SmallMoleculeDrug DB04896 Milnacipran Thumb 23.2%
7 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 22.1%
8 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb 21.4%
9 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00141 N-Acetylglucosamine Thumb 20.7%
10 Approved SmallMoleculeDrug DB00289 Atomoxetine Thumb 20.6%
11 Nutraceutical SmallMoleculeDrug DB00116 Tetrahydrofolic acid Thumb 20.1%
12 Approved;
Investigational		 SmallMoleculeDrug DB09481 Magnesium carbonate Thumb 20.1%
13 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01520 Tenocyclidine Thumb 19.8%
14 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 19.8%
15 Approved;
Investigational		 BiotechDrug DB00028 Immune Globulin Human Thumb 19.5%
16 Approved;
Nutraceutical		 SmallMoleculeDrug DB00126 Vitamin C Thumb 19.1%
17 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 19.0%
18 Experimental SmallMoleculeDrug DB02007 alpha-D-glucose 6-phosphate Thumb 18.8%
19 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00627 Niacin Thumb 18.5%
20 Investigational SmallMoleculeDrug DB06266 Lonidamine Thumb 18.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.