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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9Y233
No. Gene UniProt ID Protein Name Pathway PDB
1 PDE10A Q9Y233 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A hsa00230; hsa05032


12 known interactions (drugs) of input target (PDE10A): cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00975 Dipyridamole Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB08814 Triflusal Thumb
3 Experimental SmallMoleculeDrug DB08389 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE Thumb
4 Approved SmallMoleculeDrug DB08811 Tofisopam Thumb
5 Experimental SmallMoleculeDrug DB08383 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole Thumb
6 Experimental SmallMoleculeDrug DB08384 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline Thumb
7 Approved SmallMoleculeDrug DB00201 Caffeine Thumb
8 Experimental SmallMoleculeDrug DB08386 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB01113 Papaverine Thumb
10 Experimental SmallMoleculeDrug DB08391 6,7-DIMETHOXY-4-[(3R)-3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE Thumb
11 Experimental SmallMoleculeDrug DB08387 2-{[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline Thumb
12 Approved SmallMoleculeDrug DB09283 Trapidil Thumb


20 predicted interactions (drugs) of input target (PDE10A): cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB07954 3-isobutyl-1-methyl-7H-xanthine Thumb 44.6%
2 Approved SmallMoleculeDrug DB00651 Dyphylline Thumb 30.6%
3 Approved;
Investigational		 SmallMoleculeDrug DB00806 Pentoxifylline Thumb 26.3%
4 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb 25.9%
5 Approved;
Investigational		 SmallMoleculeDrug DB05266 Ibudilast Thumb 25.2%
6 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 24.8%
7 Approved;
Nutraceutical		 SmallMoleculeDrug DB00125 L-Arginine Thumb 24.5%
8 Approved;
Investigational		 BiotechDrug DB01278 Pramlintide Thumb 24.2%
9 Experimental SmallMoleculeDrug DB02315 Cyclic Guanosine Monophosphate Thumb 23.8%
10 Approved;
Investigational		 SmallMoleculeDrug DB05219 Crisaborole Thumb 23.1%
11 Approved SmallMoleculeDrug DB01656 Roflumilast Thumb 22.0%
12 Approved;
Nutraceutical		 SmallMoleculeDrug DB00173 Adenine Thumb 21.9%
13 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 21.9%
14 Experimental SmallMoleculeDrug DB01959 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb 21.7%
15 Experimental SmallMoleculeDrug DB06909 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Thumb 21.4%
16 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 20.2%
17 Approved BiotechDrug DB00040 Glucagon recombinant Thumb 20.1%
18 Approved;
Investigational		 SmallMoleculeDrug DB11994 Diacerein Thumb 20.0%
19 Approved;
Investigational		 SmallMoleculeDrug DB00203 Sildenafil Thumb 19.6%
20 Investigational SmallMoleculeDrug DB06660 Saredutant Thumb 19.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.