QuartataWeb 1.0

15 known interactions (drugs) of input target (IGF1R): Insulin-like growth factor 1 receptor

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Experimental	SmallMoleculeDrug	DB07474	3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE	CC1=CC(=CC2=C1N=C(N2)C1=C(NCC2=NC=CC=C2)C=CNC1=O)N1C=CN=C1
2	Investigational	BiotechDrug	DB12250	Cixutumumab	NA
3	Approved; Investigational	BiotechDrug	DB00030	Insulin Human	NA
4	Investigational	SmallMoleculeDrug	DB06075	Linsitinib	C[C@@]1(O)C[C@@H](C1)C1=NC(=C2N1C=CN=C2N)C1=CC=C2C=CC(=NC2=C1)C1=CC=CC=C1
5	Experimental	SmallMoleculeDrug	DB04395	Phosphoaminophosphonic Acid-Adenylate Ester	NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H](CO[P@](O)(=O)O[P@@](O)(=O)NP(O)(O)=O)[C@H](O)[C@H]1O
6	Investigational	SmallMoleculeDrug	DB05184	XL228	NA
7	Approved; Investigational	BiotechDrug	DB01277	Mecasermin	NA
8	Approved; Investigational; Withdrawn	BiotechDrug	DB09098	Somatrem	NA
9	Approved	BiotechDrug	DB00071	Insulin Pork	NA
10	Approved	BiotechDrug	DB00047	Insulin Glargine	NA
11	Approved	BiotechDrug	DB00046	Insulin Lispro	NA
12	Investigational	SmallMoleculeDrug	DB05023	ATL1101	NA
13	Experimental	SmallMoleculeDrug	DB07156	(4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione	BrC1=CC=C2C(=O)NC(=O)\C(=C/NC3=CC=C(CN4CCCC4)C=C3)C2=C1
14	Approved; Investigational	SmallMoleculeDrug	DB12267	Brigatinib	COC1=CC(=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1)N1CCC(CC1)N1CCN(C)CC1
15	Investigational	SmallMoleculeDrug	DB05897	rhIGFBP-3	NA

20 predicted interactions (drugs) of input target (IGF1R): Insulin-like growth factor 1 receptor

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Approved; Nutraceutical; Vet approved	SmallMoleculeDrug	DB00145	Glycine	NCC(O)=O	50.2%
2	Approved	BiotechDrug	DB09564	Insulin Degludec	NA	32.7%
3	Approved; Investigational	SmallMoleculeDrug	DB12010	Fostamatinib	COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC	31.7%
4	Approved	BiotechDrug	DB01309	Insulin Glulisine	NA	29.3%
5	Approved; Investigational	SmallMoleculeDrug	DB11638	Artenimol	[H][C@@]1(C)CC[C@@]2([H])[C@@]([H])(C)C([H])(O)O[C@]3([H])O[C@@]4(C)CC[C@]1([H])[C@@]23OO4	28.5%
6	Approved	BiotechDrug	DB01307	Insulin Detemir	NA	27.1%
7	Experimental	SmallMoleculeDrug	DB08513	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID	CC1=CC(NC2=NC(NC3=CC=C(CC(O)=O)C=C3)=NC=C2C(N)=O)=CC=C1	26.7%
8	Experimental	SmallMoleculeDrug	DB07177	(5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID	[H]C(CCCC(O)=O)=C([H])CC1C(\C([H])=C(/[H])C(=O)CCCCC)C(O)CC1=O	26.6%
9	Approved	SmallMoleculeDrug	DB09129	Chromic chloride	[Cl-].[Cl-].[Cl-].[Cr+3]	25.6%
10	Investigational	SmallMoleculeDrug	DB05078	AER001	NA	25.5%
11	Investigational	SmallMoleculeDrug	DB05115	NN344	NA	25.0%
12	Approved; Investigational; Nutraceutical	SmallMoleculeDrug	DB00120	L-Phenylalanine	N[C@@H](CC1=CC=CC=C1)C(O)=O	24.8%
13	Experimental	SmallMoleculeDrug	DB03909	Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate	[H][C@]1(COP(O)(=O)OP(O)(=O)CP(O)(O)=O)O[C@@]([H])(N2C=NC3=C(N)N=CN=C23)[C@]([H])(O)[C@]1([H])O	24.1%
14	Experimental	SmallMoleculeDrug	DB04400	L-erythro-7,8-dihydrobiopterin	[H][C@@](C)(O)[C@]([H])(O)C1=NC2=C(NC1)NC(=N)N=C2O	23.3%
15	Experimental	SmallMoleculeDrug	DB03552	3-Tyrosine	N[C@@H](CC1=CC=CC(O)=C1)C(O)=O	22.8%
16	Approved	BiotechDrug	DB01306	Insulin Aspart	NA	22.4%
17	Experimental	SmallMoleculeDrug	DB08231	Myristic acid	CCCCCCCCCCCCCC(O)=O	22.3%
18	Approved; Investigational	SmallMoleculeDrug	DB08901	Ponatinib	CN1CCN(CC2=CC=C(NC(=O)C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C)C=C3)C=C2C(F)(F)F)CC1	22.2%
19	Experimental	SmallMoleculeDrug	DB07983	1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID	COC1=CC=C2N(C(=O)C3=CC=C(I)C=C3)C(C)=C(CC(O)=O)C2=C1	21.6%
20	Approved; Investigational	SmallMoleculeDrug	DB01254	Dasatinib	CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1	21.4%