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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08069
No. Gene UniProt ID Protein Name Pathway PDB
1 IGF1R P08069 Insulin-like growth factor 1 receptor hsa01521; hsa01522; hsa04010; hsa04014; hsa04015; hsa04066; hsa04068; hsa04114; hsa04140; hsa04144; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04510; hsa04520; hsa04550; hsa04730; hsa04913; hsa04914; hsa05200; hsa05202; hsa05205; hsa05214; hsa05215; hsa05218; hsa05224; hsa05225 1IGR; 1JQH; 1K3A; 1M7N; 1P4O; 2OJ9; 2ZM3; 3D94; 3F5P; 3I81; 3LVP; 3LW0; 3NW5; 3NW6; 3NW7; 3O23; 3QQU; 4D2R; 4XSS

15 known interactions (drugs) of input target (IGF1R): Insulin-like growth factor 1 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB07474 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE Thumb
2 Investigational BiotechDrug DB12250 Cixutumumab Thumb
3 Approved;
BiotechDrug DB00030 Insulin Human Thumb
4 Investigational SmallMoleculeDrug DB06075 Linsitinib Thumb
5 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb
6 Investigational SmallMoleculeDrug DB05184 XL228 Thumb
7 Approved;
BiotechDrug DB01277 Mecasermin Thumb
8 Approved;
BiotechDrug DB09098 Somatrem Thumb
9 Approved BiotechDrug DB00071 Insulin Pork Thumb
10 Approved BiotechDrug DB00047 Insulin Glargine Thumb
11 Approved BiotechDrug DB00046 Insulin Lispro Thumb
12 Investigational SmallMoleculeDrug DB05023 ATL1101 Thumb
13 Experimental SmallMoleculeDrug DB07156 (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione Thumb
14 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb
15 Investigational SmallMoleculeDrug DB05897 rhIGFBP-3 Thumb

20 predicted interactions (drugs) of input target (IGF1R): Insulin-like growth factor 1 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb 50.2%
2 Approved BiotechDrug DB09564 Insulin Degludec Thumb 32.7%
3 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 31.7%
4 Approved BiotechDrug DB01309 Insulin Glulisine Thumb 29.3%
5 Approved;
SmallMoleculeDrug DB11638 Artenimol Thumb 28.5%
6 Approved BiotechDrug DB01307 Insulin Detemir Thumb 27.1%
7 Experimental SmallMoleculeDrug DB08513 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Thumb 26.7%
8 Experimental SmallMoleculeDrug DB07177 (5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID Thumb 26.6%
9 Approved SmallMoleculeDrug DB09129 Chromic chloride Thumb 25.6%
10 Investigational SmallMoleculeDrug DB05078 AER001 Thumb 25.5%
11 Investigational SmallMoleculeDrug DB05115 NN344 Thumb 25.0%
12 Approved;
SmallMoleculeDrug DB00120 L-Phenylalanine Thumb 24.8%
13 Experimental SmallMoleculeDrug DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Thumb 24.1%
14 Experimental SmallMoleculeDrug DB04400 L-erythro-7,8-dihydrobiopterin Thumb 23.3%
15 Experimental SmallMoleculeDrug DB03552 3-Tyrosine Thumb 22.8%
16 Approved BiotechDrug DB01306 Insulin Aspart Thumb 22.4%
17 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 22.3%
18 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 22.2%
19 Experimental SmallMoleculeDrug DB07983 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID Thumb 21.6%
20 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 21.4%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.