QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P41240
No. Gene UniProt ID Protein Name Pathway PDB
1 CSK P41240 Tyrosine-protein kinase CSK hsa05120 1BYG; 1CSK; 3D7T; 3D7U; 3EAC; 3EAZ


4 known interactions (drugs) of input target (CSK): Tyrosine-protein kinase CSK
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
3 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb


20 predicted interactions (drugs) of input target (CSK): Tyrosine-protein kinase CSK
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 47.3%
2 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 42.9%
3 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 36.3%
4 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb 35.0%
5 Approved;
Investigational		 SmallMoleculeDrug DB00398 Sorafenib Thumb 33.7%
6 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 31.6%
7 Investigational SmallMoleculeDrug DB04879 Vatalanib Thumb 31.2%
8 Approved;
Investigational		 SmallMoleculeDrug DB01268 Sunitinib Thumb 30.3%
9 Approved;
Investigational		 SmallMoleculeDrug DB09078 Lenvatinib Thumb 28.5%
10 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 28.3%
11 Investigational BiotechDrug DB06101 IMC-1C11 Thumb 26.9%
12 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 26.2%
13 Investigational;
Nutraceutical		 SmallMoleculeDrug DB00171 ATP Thumb 25.1%
14 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb 24.0%
15 Investigational SmallMoleculeDrug DB05932 Denibulin Thumb 23.9%
16 Approved;
Investigational		 SmallMoleculeDrug DB06626 Axitinib Thumb 23.5%
17 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 23.1%
18 Approved;
Investigational		 SmallMoleculeDrug DB06595 Midostaurin Thumb 23.0%
19 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 21.3%
20 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 20.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.