Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics


Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P07948
No. Gene UniProt ID Protein Name Pathway PDB
1 LYN P07948 Tyrosine-protein kinase Lyn hsa04062; hsa04064; hsa04611; hsa04662; hsa04664; hsa04666; hsa04730; hsa05120; hsa05167; hsa05169; hsa05203 1W1F; 1WA7; 3A4O

6 known interactions (drugs) of input target (LYN): Tyrosine-protein kinase Lyn
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb
2 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb
3 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
4 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb
5 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb
6 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb

20 predicted interactions (drugs) of input target (LYN): Tyrosine-protein kinase Lyn
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 46.5%
2 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 36.5%
3 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 33.5%
4 Investigational SmallMoleculeDrug DB05184 XL228 Thumb 32.5%
5 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 32.2%
6 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 31.8%
7 Experimental SmallMoleculeDrug DB01962 Phosphonotyrosine Thumb 31.6%
8 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb 31.1%
9 Approved;
SmallMoleculeDrug DB09130 Copper Thumb 29.9%
10 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 29.7%
11 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 28.5%
12 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 28.0%
13 Experimental SmallMoleculeDrug DB08056 N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine Thumb 26.0%
14 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 25.6%
15 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 25.4%
16 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 25.1%
17 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 25.0%
18 Experimental SmallMoleculeDrug DB08057 N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine Thumb 24.1%
19 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 24.0%
20 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 23.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.