QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P29120
No. Gene UniProt ID Protein Name Pathway PDB
1 PCSK1 P29120 Neuroendocrine convertase 1 NA NA


2 known interactions (drugs) of input target (PCSK1): Neuroendocrine convertase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved BiotechDrug DB00071 Insulin Pork Thumb
2 Approved;
Investigational		 BiotechDrug DB00030 Insulin Human Thumb


20 predicted interactions (drugs) of input target (PCSK1): Neuroendocrine convertase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 28.4%
2 Approved;
Investigational		 BiotechDrug DB01277 Mecasermin Thumb 18.3%
3 Approved BiotechDrug DB00047 Insulin Glargine Thumb 17.2%
4 Approved BiotechDrug DB00046 Insulin Lispro Thumb 16.8%
5 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01234 Dexamethasone Thumb 16.8%
6 Approved;
Vet approved		 SmallMoleculeDrug DB00626 Bacitracin Thumb 15.7%
7 Investigational SmallMoleculeDrug DB05023 ATL1101 Thumb 15.6%
8 Investigational;
Nutraceutical		 SmallMoleculeDrug DB00171 ATP Thumb 15.6%
9 Experimental SmallMoleculeDrug DB03028 1h-Benoximidazole-2-Carboxylic Acid Thumb 15.5%
10 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 15.0%
11 Approved;
Investigational;
Withdrawn		 BiotechDrug DB00013 Urokinase Thumb 14.7%
12 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 14.7%
13 Investigational BiotechDrug DB12250 Cixutumumab Thumb 14.6%
14 Experimental SmallMoleculeDrug DB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Thumb 14.6%
15 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 14.1%
16 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01110 Miconazole Thumb 13.9%
17 Approved;
Vet approved		 SmallMoleculeDrug DB00798 Gentamicin Thumb 13.7%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 13.2%
19 Approved;
Vet approved		 SmallMoleculeDrug DB00741 Hydrocortisone Thumb 13.1%
20 Experimental SmallMoleculeDrug DB08740 CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE Thumb 12.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.