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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O43519
No. Gene UniProt ID Protein Name Pathway PDB
1 RET O43519 RET proto-oncogene NA NA

2 known interactions (drugs) of input target (RET): RET proto-oncogene
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Investigational SmallMoleculeDrug DB05014 XL999 Thumb
2 Approved SmallMoleculeDrug DB00619 Imatinib Thumb

20 predicted interactions (drugs) of input target (RET): RET proto-oncogene
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 49.7%
2 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 39.4%
3 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 38.7%
4 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 36.4%
5 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb 34.2%
6 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 34.1%
7 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 33.2%
8 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 32.8%
9 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 31.6%
10 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 27.6%
11 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 27.3%
12 Investigational;
SmallMoleculeDrug DB00171 ATP Thumb 27.2%
13 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 26.9%
14 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 22.4%
15 Approved;
SmallMoleculeDrug DB09221 Polaprezinc Thumb 21.4%
16 Approved;
SmallMoleculeDrug DB04868 Nilotinib Thumb 21.1%
17 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 19.6%
18 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 19.5%
19 Approved;
BiotechDrug DB00102 Becaplermin Thumb 19.0%
20 Investigational SmallMoleculeDrug DB06469 Lestaurtinib Thumb 18.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.