QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q7Z2H8
No. Gene UniProt ID Protein Name Pathway PDB
1 SLC36A1 Q7Z2H8 Proton-coupled amino acid transporter 1 hsa04974 NA


2 known interactions (drugs) of input target (SLC36A1): Proton-coupled amino acid transporter 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00160 L-Alanine Thumb
2 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb


20 predicted interactions (drugs) of input target (SLC36A1): Proton-coupled amino acid transporter 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 45.1%
2 Nutraceutical SmallMoleculeDrug DB00116 Tetrahydrofolic acid Thumb 20.6%
3 Approved SmallMoleculeDrug DB00780 Phenelzine Thumb 19.9%
4 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb 18.7%
5 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 18.6%
6 Experimental SmallMoleculeDrug DB07069 3-Hydroxyhippuric acid Thumb 16.9%
7 Experimental SmallMoleculeDrug DB01699 (4e)-4-Aminohex-4-Enoic Acid Thumb 15.6%
8 Approved;
Nutraceutical		 SmallMoleculeDrug DB00151 L-Cysteine Thumb 15.4%
9 Approved SmallMoleculeDrug DB01080 Vigabatrin Thumb 13.1%
10 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00118 Ademetionine Thumb 13.0%
11 Approved;
Nutraceutical		 SmallMoleculeDrug DB00129 Ornithine Thumb 13.0%
12 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00119 Pyruvic acid Thumb 12.9%
13 Experimental SmallMoleculeDrug DB04235 4-Amino Hexanoic Acid Thumb 12.5%
14 Experimental SmallMoleculeDrug DB08060 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID Thumb 12.2%
15 Experimental SmallMoleculeDrug DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose Thumb 11.5%
16 Approved;
Investigational;
Withdrawn		 BiotechDrug DB00092 Alefacept Thumb 11.1%
17 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 11.0%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB00170 Menadione Thumb 11.0%
19 Experimental SmallMoleculeDrug DB02079 Aminooxyacetic acid Thumb 10.8%
20 Approved SmallMoleculeDrug DB01073 Fludarabine Thumb 10.7%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.