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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P07339
No. Gene UniProt ID Protein Name Pathway PDB
1 CTSD P07339 Cathepsin D hsa04071; hsa04140; hsa04142; hsa04210; hsa04915; hsa05152 1LYA; 1LYB; 1LYW; 4OBZ; 4OC6; 4OD9


7 known interactions (drugs) of input target (CTSD): Cathepsin D
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 BiotechDrug DB00030 Insulin Human Thumb
2 Experimental SmallMoleculeDrug DB08740 CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE Thumb
3 Experimental SmallMoleculeDrug DB07542 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID Thumb
4 Approved BiotechDrug DB00071 Insulin Pork Thumb
5 Experimental SmallMoleculeDrug DB03096 N-Aminoethylmorpholine Thumb
6 Experimental SmallMoleculeDrug DB03028 1h-Benoximidazole-2-Carboxylic Acid Thumb
7 Experimental SmallMoleculeDrug DB02216 S-Methylcysteine Thumb


20 predicted interactions (drugs) of input target (CTSD): Cathepsin D
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 35.3%
2 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 21.9%
3 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb 21.3%
4 Approved;
Investigational		 BiotechDrug DB01277 Mecasermin Thumb 21.3%
5 Approved;
Vet approved		 SmallMoleculeDrug DB00741 Hydrocortisone Thumb 20.1%
6 Approved BiotechDrug DB11626 Tasonermin Thumb 19.3%
7 Approved;
Nutraceutical		 SmallMoleculeDrug DB01373 Calcium Thumb 19.3%
8 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00143 Glutathione Thumb 18.9%
9 Approved;
Investigational		 SmallMoleculeDrug DB00669 Sumatriptan Thumb 18.8%
10 Experimental SmallMoleculeDrug DB11345 (S)-camphor Thumb 18.5%
11 Experimental SmallMoleculeDrug DB04530 S,S-(2-Hydroxyethyl)Thiocysteine Thumb 18.5%
12 Approved BiotechDrug DB00036 Coagulation factor VIIa Recombinant Human Thumb 18.2%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00626 Bacitracin Thumb 18.1%
14 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01108 Trilostane Thumb 18.0%
15 Approved;
Investigational		 SmallMoleculeDrug DB09213 Dexibuprofen Thumb 18.0%
16 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb 17.8%
17 Investigational;
Nutraceutical		 SmallMoleculeDrug DB00171 ATP Thumb 17.8%
18 Approved SmallMoleculeDrug DB00768 Olopatadine Thumb 17.5%
19 Approved;
Investigational		 SmallMoleculeDrug DB09258 Bemiparin Thumb 17.3%
20 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00155 L-Citrulline Thumb 17.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.