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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P23434
No. Gene UniProt ID Protein Name Pathway PDB
1 GCSH P23434 Glycine cleavage system H protein, mitochondrial hsa00260; hsa00630; hsa01100; hsa01200 NA

3 known interactions (drugs) of input target (GCSH): Glycine cleavage system H protein, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB03760 Dihydrolipoic Acid Thumb
2 Approved;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb
3 Experimental SmallMoleculeDrug DB03187 6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Thumb

20 predicted interactions (drugs) of input target (GCSH): Glycine cleavage system H protein, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB03758 Radicicol Thumb 39.9%
2 Approved;
SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 26.2%
3 Nutraceutical SmallMoleculeDrug DB00116 Tetrahydrofolic acid Thumb 21.6%
4 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 17.6%
5 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 16.8%
6 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 16.7%
7 Approved;
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 16.4%
8 Approved;
SmallMoleculeDrug DB08889 Carfilzomib Thumb 16.2%
9 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 16.1%
10 Experimental SmallMoleculeDrug DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Thumb 15.8%
11 Investigational BiotechDrug DB06245 Lanoteplase Thumb 15.7%
12 Approved;
SmallMoleculeDrug DB00157 NADH Thumb 15.5%
13 Approved;
SmallMoleculeDrug DB00138 Cystine Thumb 14.8%
14 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 14.7%
15 Approved SmallMoleculeDrug DB01197 Captopril Thumb 14.5%
16 Approved;
BiotechDrug DB00028 Immune Globulin Human Thumb 14.5%
17 Approved;
BiotechDrug DB00005 Etanercept Thumb 14.5%
18 Approved BiotechDrug DB11572 Thrombin Alfa Thumb 14.0%
19 Experimental SmallMoleculeDrug DB02285 Protoporphyrin Thumb 13.9%
20 Approved;
BiotechDrug DB11300 Thrombin Thumb 13.4%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.