QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P24530
No. Gene UniProt ID Protein Name Pathway PDB
1 EDNRB P24530 Endothelin B receptor hsa04020; hsa04022; hsa04080; hsa04916; hsa04926; hsa05200 NA


7 known interactions (drugs) of input target (EDNRB): Endothelin B receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB06138 IRL-1620 Thumb
2 Investigational SmallMoleculeDrug DB06558 Tezosentan Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB06403 Ambrisentan Thumb
4 Approved SmallMoleculeDrug DB08932 Macitentan Thumb
5 Investigational SmallMoleculeDrug DB06460 Enrasentan Thumb
6 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06268 Sitaxentan Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00559 Bosentan Thumb


20 predicted interactions (drugs) of input target (EDNRB): Endothelin B receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB06677 Clazosentan Thumb 42.5%
2 Investigational SmallMoleculeDrug DB05367 Actelion-1 Thumb 38.8%
3 Investigational SmallMoleculeDrug DB04883 Darusentan Thumb 37.4%
4 Investigational SmallMoleculeDrug DB12548 Sparsentan Thumb 35.8%
5 Investigational SmallMoleculeDrug DB06199 Atrasentan Thumb 35.1%
6 Experimental SmallMoleculeDrug DB04674 2-HYDROXY-3,5-DIIODOBENZOIC ACID Thumb 33.5%
7 Investigational SmallMoleculeDrug DB05290 SPP 301 Thumb 31.9%
8 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 26.2%
9 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 26.2%
10 Approved BiotechDrug DB00036 Coagulation factor VIIa Recombinant Human Thumb 23.9%
11 Approved;
Investigational		 BiotechDrug DB00020 Sargramostim Thumb 22.8%
12 Approved SmallMoleculeDrug DB08910 Pomalidomide Thumb 21.8%
13 Approved SmallMoleculeDrug DB00201 Caffeine Thumb 21.3%
14 Experimental;
Investigational		 SmallMoleculeDrug DB08838 Agmatine Thumb 21.2%
15 Approved;
Investigational		 SmallMoleculeDrug DB01296 Glucosamine Thumb 20.7%
16 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 18.7%
17 Experimental SmallMoleculeDrug DB07272 N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE Thumb 18.6%
18 Investigational;
Withdrawn		 SmallMoleculeDrug DB00197 Troglitazone Thumb 18.3%
19 Approved;
Investigational;
Withdrawn		 BiotechDrug DB00055 Drotrecogin alfa Thumb 17.6%
20 Approved;
Vet approved		 SmallMoleculeDrug DB00508 Triflupromazine Thumb 17.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.