QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P12724
No. Gene UniProt ID Protein Name Pathway PDB
1 RNASE3 P12724 Eosinophil cationic protein hsa05310 1DYT; 1H1H; 1QMT; 2KB5; 2LVZ; 4A2O; 4A2Y; 4OWZ; 4OXB; 4OXF; 4X08


3 known interactions (drugs) of input target (RNASE3): Eosinophil cationic protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb
2 Experimental SmallMoleculeDrug DB02098 Adenosine-2'-5'-Diphosphate Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB01411 Pranlukast Thumb


20 predicted interactions (drugs) of input target (RNASE3): Eosinophil cationic protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb 36.4%
2 Experimental SmallMoleculeDrug DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Thumb 22.3%
3 Experimental SmallMoleculeDrug DB04447 1,4-Dithiothreitol Thumb 21.4%
4 Experimental SmallMoleculeDrug DB08437 Puromycin Thumb 21.3%
5 Approved SmallMoleculeDrug DB00536 Guanidine Thumb 20.3%
6 Experimental SmallMoleculeDrug DB03981 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Thumb 20.2%
7 Experimental SmallMoleculeDrug DB03900 2-Methyl-2-Propanol Thumb 19.4%
8 Experimental SmallMoleculeDrug DB07374 Anisomycin Thumb 18.4%
9 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 18.2%
10 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 16.7%
11 Approved SmallMoleculeDrug DB01003 Cromoglicic acid Thumb 15.9%
12 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01041 Thalidomide Thumb 15.7%
13 Approved;
Withdrawn		 SmallMoleculeDrug DB09092 Xanthinol Thumb 15.4%
14 Experimental SmallMoleculeDrug DB02337 S-(D-Carboxybutyl)-L-Homocysteine Thumb 15.4%
15 Experimental SmallMoleculeDrug DB03499 Malate Ion Thumb 15.3%
16 Approved SmallMoleculeDrug DB09285 Morniflumate Thumb 14.6%
17 Experimental SmallMoleculeDrug DB03959 N,O6-Disulfo-Glucosamine Thumb 14.5%
18 Experimental SmallMoleculeDrug DB03512 Uridine-2',3'-Vanadate Thumb 14.4%
19 Approved SmallMoleculeDrug DB13146 Fluciclovine (18F) Thumb 14.4%
20 Experimental SmallMoleculeDrug DB03186 U-Pi-a-Pi Thumb 13.9%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.