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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P10826
No. Gene UniProt ID Protein Name Pathway PDB
1 RARB P10826 Retinoic acid receptor beta hsa05200; hsa05222; hsa05223; hsa05226 1HRA; 1XAP; 4DM6; 4DM8; 4JYG; 4JYH; 4JYI


9 known interactions (drugs) of input target (RARB): Retinoic acid receptor beta
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Withdrawn SmallMoleculeDrug DB00926 Etretinate Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00523 Alitretinoin Thumb
3 Experimental SmallMoleculeDrug DB02877 Arotinoid acid Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00799 Tazarotene Thumb
5 Investigational SmallMoleculeDrug DB05785 LGD-1550 Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB04942 Tamibarotene Thumb
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb
8 Approved SmallMoleculeDrug DB00210 Adapalene Thumb
9 Approved SmallMoleculeDrug DB00459 Acitretin Thumb


20 predicted interactions (drugs) of input target (RARB): Retinoic acid receptor beta
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00982 Isotretinoin Thumb 43.7%
2 Approved;
Investigational		 SmallMoleculeDrug DB00307 Bexarotene Thumb 35.6%
3 Experimental SmallMoleculeDrug DB07031 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid Thumb 33.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB03756 Doconexent Thumb 30.4%
5 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb 29.4%
6 Approved SmallMoleculeDrug DB02659 Cholic Acid Thumb 27.3%
7 Experimental SmallMoleculeDrug DB07294 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid Thumb 26.5%
8 Experimental SmallMoleculeDrug DB02741 CD564 Thumb 26.0%
9 Experimental SmallMoleculeDrug DB02466 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid Thumb 25.8%
10 Experimental SmallMoleculeDrug DB03466 BMS184394 Thumb 25.5%
11 Experimental SmallMoleculeDrug DB02258 SR11254 Thumb 25.3%
12 Investigational SmallMoleculeDrug DB05467 R667 Thumb 24.5%
13 Experimental SmallMoleculeDrug DB08601 tributylstannanyl Thumb 24.1%
14 Experimental SmallMoleculeDrug DB07929 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE Thumb 24.1%
15 Approved;
Investigational		 SmallMoleculeDrug DB03088 Pidolic Acid Thumb 24.1%
16 Approved;
Investigational		 SmallMoleculeDrug DB01393 Bezafibrate Thumb 23.8%
17 Approved;
Investigational		 SmallMoleculeDrug DB00412 Rosiglitazone Thumb 22.4%
18 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 22.3%
19 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb 21.9%
20 Experimental SmallMoleculeDrug DB08175 (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Thumb 21.9%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.