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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q14749
No. Gene UniProt ID Protein Name Pathway PDB
1 GNMT Q14749 Glycine N-methyltransferase hsa00260 1R74; 2AZT


4 known interactions (drugs) of input target (GNMT): Glycine N-methyltransferase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00118 Ademetionine Thumb
3 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb
4 Experimental SmallMoleculeDrug DB01752 S-adenosyl-L-homocysteine Thumb


20 predicted interactions (drugs) of input target (GNMT): Glycine N-methyltransferase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 31.3%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00151 L-Cysteine Thumb 25.8%
3 Approved SmallMoleculeDrug DB00768 Olopatadine Thumb 21.2%
4 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb 19.8%
5 Approved SmallMoleculeDrug DB00536 Guanidine Thumb 19.8%
6 Approved;
Withdrawn		 SmallMoleculeDrug DB09092 Xanthinol Thumb 18.3%
7 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb 18.2%
8 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 18.0%
9 Experimental SmallMoleculeDrug DB02751 Glycocyamine Thumb 16.3%
10 Nutraceutical SmallMoleculeDrug DB00116 Tetrahydrofolic acid Thumb 15.5%
11 Experimental SmallMoleculeDrug DB01915 S-Hydroxycysteine Thumb 15.5%
12 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb 15.3%
13 Approved;
Investigational		 SmallMoleculeDrug DB00613 Amodiaquine Thumb 15.0%
14 Approved;
Nutraceutical		 SmallMoleculeDrug DB00160 L-Alanine Thumb 14.9%
15 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb 14.9%
16 Approved;
Investigational		 SmallMoleculeDrug DB00738 Pentamidine Thumb 14.8%
17 Approved;
Investigational		 SmallMoleculeDrug DB09462 Glycerin Thumb 14.7%
18 Experimental SmallMoleculeDrug DB02098 Adenosine-2'-5'-Diphosphate Thumb 14.6%
19 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb 14.5%
20 Approved SmallMoleculeDrug DB00674 Galantamine Thumb 14.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.