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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P16234
No. Gene UniProt ID Protein Name Pathway PDB
1 PDGFRA P16234 Platelet-derived growth factor receptor alpha hsa01521; hsa04010; hsa04014; hsa04015; hsa04020; hsa04072; hsa04144; hsa04151; hsa04510; hsa04540; hsa04630; hsa04810; hsa05163; hsa05166; hsa05200; hsa05206; hsa05214; hsa05215; hsa05218; hsa05230; hsa05231 1GQ5

12 known interactions (drugs) of input target (PDGFRA): Platelet-derived growth factor receptor alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb
2 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb
3 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
4 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb
5 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb
6 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb
7 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
8 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb
9 Investigational SmallMoleculeDrug DB05146 XL820 Thumb
10 Approved;
BiotechDrug DB06043 Olaratumab Thumb
11 Approved;
BiotechDrug DB00102 Becaplermin Thumb
12 Approved SmallMoleculeDrug DB00619 Imatinib Thumb

20 predicted interactions (drugs) of input target (PDGFRA): Platelet-derived growth factor receptor alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 63.9%
2 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 62.9%
3 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb 57.6%
4 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 55.8%
5 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 54.7%
6 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 53.2%
7 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 47.3%
8 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 43.8%
9 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 42.1%
10 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 41.4%
11 Approved;
SmallMoleculeDrug DB04868 Nilotinib Thumb 40.4%
12 Approved;
SmallMoleculeDrug DB08875 Cabozantinib Thumb 33.6%
13 Investigational SmallMoleculeDrug DB04879 Vatalanib Thumb 32.5%
14 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 32.1%
15 Experimental SmallMoleculeDrug DB01962 Phosphonotyrosine Thumb 31.9%
16 Investigational SmallMoleculeDrug DB12874 Quizartinib Thumb 31.7%
17 Approved;
BiotechDrug DB09103 Ancestim Thumb 31.2%
18 Approved;
SmallMoleculeDrug DB09221 Polaprezinc Thumb 30.5%
19 Investigational SmallMoleculeDrug DB06469 Lestaurtinib Thumb 29.9%
20 Investigational BiotechDrug DB06101 IMC-1C11 Thumb 29.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.