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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q02763
No. Gene UniProt ID Protein Name Pathway PDB
1 TEK Q02763 Angiopoietin-1 receptor hsa04010; hsa04014; hsa04015; hsa04066; hsa04151; hsa05323 1FVR; 2GY5; 2GY7; 2OO8; 2OSC; 2P4I; 2WQB; 3BEA; 3L8P; 4K0V; 4X3J


6 known interactions (drugs) of input target (TEK): Angiopoietin-1 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb
2 Approved;
Vet approved		 SmallMoleculeDrug DB00415 Ampicillin Thumb
3 Experimental SmallMoleculeDrug DB08221 N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE Thumb
4 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb


20 predicted interactions (drugs) of input target (TEK): Angiopoietin-1 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 47.4%
2 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 43.1%
3 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 36.3%
4 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 36.1%
5 Approved;
Investigational		 SmallMoleculeDrug DB09078 Lenvatinib Thumb 34.5%
6 Approved;
Investigational		 SmallMoleculeDrug DB01268 Sunitinib Thumb 32.6%
7 Approved;
Investigational		 SmallMoleculeDrug DB08875 Cabozantinib Thumb 32.0%
8 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 31.3%
9 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 30.8%
10 Approved;
Investigational		 SmallMoleculeDrug DB00398 Sorafenib Thumb 30.0%
11 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 29.8%
12 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 28.6%
13 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 28.3%
14 Experimental SmallMoleculeDrug DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb 27.4%
15 Experimental SmallMoleculeDrug DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb 24.4%
16 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 24.0%
17 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 22.4%
18 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 21.6%
19 Approved SmallMoleculeDrug DB00200 Hydroxocobalamin Thumb 21.5%
20 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 21.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.