QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P21731
No. Gene UniProt ID Protein Name Pathway PDB
1 TBXA2R P21731 Thromboxane A2 receptor hsa04020; hsa04080; hsa04611 1LBN


3 known interactions (drugs) of input target (TBXA2R): Thromboxane A2 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB06739 Seratrodast Thumb
2 Approved SmallMoleculeDrug DB09285 Morniflumate Thumb
3 Approved SmallMoleculeDrug DB01207 Ridogrel Thumb


20 predicted interactions (drugs) of input target (TBXA2R): Thromboxane A2 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb 21.5%
2 Approved SmallMoleculeDrug DB00795 Sulfasalazine Thumb 17.9%
3 Experimental SmallMoleculeDrug DB04599 Aniracetam Thumb 17.0%
4 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00143 Glutathione Thumb 16.3%
5 Investigational SmallMoleculeDrug DB04725 Licofelone Thumb 16.1%
6 Approved;
Investigational		 SmallMoleculeDrug DB00861 Diflunisal Thumb 16.0%
7 Approved;
Investigational		 SmallMoleculeDrug DB01017 Minocycline Thumb 15.7%
8 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 15.1%
9 Approved;
Investigational		 SmallMoleculeDrug DB08814 Triflusal Thumb 15.1%
10 Experimental SmallMoleculeDrug DB02189 2',3'-Dideoxyadenosine-5'-Triphosphate Thumb 14.8%
11 Experimental SmallMoleculeDrug DB02098 Adenosine-2'-5'-Diphosphate Thumb 14.6%
12 Approved;
Investigational		 SmallMoleculeDrug DB01083 Orlistat Thumb 14.0%
13 Experimental SmallMoleculeDrug DB08273 4-HYDROXY-5-IODO-3-NITROPHENYLACETYL-EPSILON-AMINOCAPROIC ACID ANION Thumb 13.9%
14 Experimental SmallMoleculeDrug DB02337 S-(D-Carboxybutyl)-L-Homocysteine Thumb 13.8%
15 Investigational SmallMoleculeDrug DB12961 Leukotriene B4 Thumb 13.8%
16 Investigational SmallMoleculeDrug DB05767 Andrographolide Thumb 13.6%
17 Approved SmallMoleculeDrug DB01600 Tiaprofenic acid Thumb 13.2%
18 Approved SmallMoleculeDrug DB00471 Montelukast Thumb 13.2%
19 Approved;
Investigational		 SmallMoleculeDrug DB00605 Sulindac Thumb 13.2%
20 Approved SmallMoleculeDrug DB00594 Amiloride Thumb 13.1%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.