QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P11274
No. Gene UniProt ID Protein Name Pathway PDB
1 BCR P11274 Breakpoint cluster region protein hsa05200; hsa05220 1K1F; 2AIN


3 known interactions (drugs) of input target (BCR): Breakpoint cluster region protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb
3 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb


20 predicted interactions (drugs) of input target (BCR): Breakpoint cluster region protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 65.4%
2 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 47.0%
3 Investigational SmallMoleculeDrug DB05184 XL228 Thumb 41.4%
4 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 36.2%
5 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 34.5%
6 Investigational;
Nutraceutical		 SmallMoleculeDrug DB00171 ATP Thumb 34.4%
7 Experimental SmallMoleculeDrug DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb 33.0%
8 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 31.4%
9 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 29.7%
10 Approved BiotechDrug DB00039 Palifermin Thumb 29.1%
11 Experimental SmallMoleculeDrug DB01962 Phosphonotyrosine Thumb 28.3%
12 Approved;
Investigational		 SmallMoleculeDrug DB00398 Sorafenib Thumb 27.0%
13 Approved;
Investigational		 SmallMoleculeDrug DB09078 Lenvatinib Thumb 26.8%
14 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 26.4%
15 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 25.9%
16 Approved;
Investigational		 SmallMoleculeDrug DB01268 Sunitinib Thumb 25.0%
17 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 24.1%
18 Approved;
Investigational		 SmallMoleculeDrug DB04868 Nilotinib Thumb 23.8%
19 Experimental SmallMoleculeDrug DB07831 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE Thumb 22.6%
20 Experimental SmallMoleculeDrug DB01863 Inositol 1,3,4,5-Tetrakisphosphate Thumb 22.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.