Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics


Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P09429
No. Gene UniProt ID Protein Name Pathway PDB
1 HMGB1 P09429 High mobility group protein B1 hsa03410; hsa04140; hsa04217 2LY4; 2RTU; 2YRQ

1 known interactions (drugs) of input target (HMGB1): High mobility group protein B1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Investigational SmallMoleculeDrug DB05869 Ethyl pyruvate Thumb

20 predicted interactions (drugs) of input target (HMGB1): High mobility group protein B1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB01296 Glucosamine Thumb 22.0%
2 Investigational SmallMoleculeDrug DB05767 Andrographolide Thumb 20.5%
3 Approved;
SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 20.3%
4 Approved;
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 20.2%
5 Investigational SmallMoleculeDrug DB05412 Talmapimod Thumb 18.9%
6 Approved;
SmallMoleculeDrug DB13751 Glycyrrhizic acid Thumb 18.8%
7 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 17.6%
8 Approved;
SmallMoleculeDrug DB00125 L-Arginine Thumb 17.5%
9 Approved;
SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb 17.1%
10 Approved;
SmallMoleculeDrug DB05676 Apremilast Thumb 14.6%
11 Investigational SmallMoleculeDrug DB05513 Atiprimod Thumb 13.8%
12 Approved;
Vet approved
SmallMoleculeDrug DB00668 Epinephrine Thumb 13.8%
13 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 13.7%
14 Experimental SmallMoleculeDrug DB08342 S-PALMITOYL-L-CYSTEINE Thumb 13.5%
15 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 12.8%
16 Approved BiotechDrug DB00065 Infliximab Thumb 12.7%
17 Approved BiotechDrug DB11572 Thrombin Alfa Thumb 12.6%
18 Investigational SmallMoleculeDrug DB12140 Dilmapimod Thumb 12.6%
19 Approved BiotechDrug DB09310 Coagulation Factor XIII A-Subunit (Recombinant) Thumb 12.5%
20 Investigational BiotechDrug DB05110 VIR201 Thumb 12.2%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.