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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P36888
No. Gene UniProt ID Protein Name Pathway PDB
1 FLT3 P36888 Receptor-type tyrosine-protein kinase FLT3 hsa04010; hsa04014; hsa04151; hsa04640; hsa05200; hsa05202; hsa05221; hsa05230 1RJB; 3QS7; 3QS9; 4RT7; 4XUF


13 known interactions (drugs) of input target (FLT3): Receptor-type tyrosine-protein kinase FLT3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Investigational SmallMoleculeDrug DB05465 Tandutinib Thumb
2 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB01268 Sunitinib Thumb
4 Investigational SmallMoleculeDrug DB06469 Lestaurtinib Thumb
5 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb
6 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb
7 Approved;
Investigational
SmallMoleculeDrug DB06595 Midostaurin Thumb
8 Approved;
Investigational
SmallMoleculeDrug DB12010 Fostamatinib Thumb
9 Approved;
Investigational
SmallMoleculeDrug DB00398 Sorafenib Thumb
10 Investigational SmallMoleculeDrug DB12874 Quizartinib Thumb
11 Approved;
Investigational
SmallMoleculeDrug DB08901 Ponatinib Thumb
12 Approved;
Investigational
SmallMoleculeDrug DB12267 Brigatinib Thumb
13 Investigational SmallMoleculeDrug DB05014 XL999 Thumb


20 predicted interactions (drugs) of input target (FLT3): Receptor-type tyrosine-protein kinase FLT3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 64.8%
2 Approved;
Investigational
SmallMoleculeDrug DB09078 Lenvatinib Thumb 63.2%
3 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 62.1%
4 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 61.3%
5 Approved;
Investigational
SmallMoleculeDrug DB01254 Dasatinib Thumb 58.9%
6 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 58.2%
7 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 44.4%
8 Approved;
Investigational
SmallMoleculeDrug DB08875 Cabozantinib Thumb 43.0%
9 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 42.9%
10 Investigational SmallMoleculeDrug DB04879 Vatalanib Thumb 42.8%
11 Investigational BiotechDrug DB06101 IMC-1C11 Thumb 42.4%
12 Approved;
Investigational
SmallMoleculeDrug DB06626 Axitinib Thumb 39.3%
13 Approved;
Investigational
BiotechDrug DB00102 Becaplermin Thumb 36.5%
14 Approved;
Investigational
SmallMoleculeDrug DB04868 Nilotinib Thumb 35.1%
15 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 35.0%
16 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 34.4%
17 Approved;
Investigational
SmallMoleculeDrug DB09221 Polaprezinc Thumb 34.2%
18 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 32.5%
19 Investigational SmallMoleculeDrug DB05184 XL228 Thumb 32.4%
20 Approved BiotechDrug DB00039 Palifermin Thumb 32.0%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.