QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P01031
No. Gene UniProt ID Protein Name Pathway PDB
1 C5 P01031 Complement C5 hsa04610; hsa05020; hsa05133; hsa05150; hsa05168; hsa05322 1CFA; 1KJS; 1XWE; 3CU7; 3HQA; 3HQB; 3KLS; 3KM9; 3PRX; 3PVM; 4A5W; 4E0S; 4P39; 4UU9


4 known interactions (drugs) of input target (C5): Complement C5
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb
2 Approved;
Investigational		 BiotechDrug DB01257 Eculizumab Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb
4 Approved;
Investigational		 BiotechDrug DB00028 Immune Globulin Human Thumb


20 predicted interactions (drugs) of input target (C5): Complement C5
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 26.0%
2 Approved;
Investigational		 BiotechDrug DB00074 Basiliximab Thumb 23.7%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00151 L-Cysteine Thumb 23.0%
4 Investigational BiotechDrug DB06492 Mirococept Thumb 22.6%
5 Approved;
Investigational		 BiotechDrug DB00095 Efalizumab Thumb 22.2%
6 Experimental SmallMoleculeDrug DB01915 S-Hydroxycysteine Thumb 20.0%
7 Approved;
Investigational		 BiotechDrug DB00075 Muromonab Thumb 19.0%
8 Approved;
Investigational		 BiotechDrug DB00078 Ibritumomab tiuxetan Thumb 18.4%
9 Approved BiotechDrug DB00054 Abciximab Thumb 17.8%
10 Approved;
Investigational		 BiotechDrug DB00110 Palivizumab Thumb 17.7%
11 Investigational;
Withdrawn		 BiotechDrug DB00111 Daclizumab Thumb 17.2%
12 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB04224 Oleic Acid Thumb 16.8%
13 Approved;
Investigational		 BiotechDrug DB00072 Trastuzumab Thumb 16.7%
14 Approved BiotechDrug DB00002 Cetuximab Thumb 16.3%
15 Approved;
Investigational		 BiotechDrug DB00112 Bevacizumab Thumb 15.6%
16 Approved SmallMoleculeDrug DB00515 Cisplatin Thumb 15.6%
17 Approved SmallMoleculeDrug DB01094 Hesperetin Thumb 15.3%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB01373 Calcium Thumb 14.9%
19 Approved;
Investigational		 SmallMoleculeDrug DB03247 Flavin mononucleotide Thumb 14.9%
20 Approved SmallMoleculeDrug DB11093 Calcium Citrate Thumb 14.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.