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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q14534
No. Gene UniProt ID Protein Name Pathway PDB
1 SQLE Q14534 Squalene monooxygenase hsa00100; hsa01100 NA

5 known interactions (drugs) of input target (SQLE): Squalene monooxygenase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB01091 Butenafine Thumb
2 Investigational SmallMoleculeDrug DB04927 NM100060 Thumb
3 Approved;
Vet approved
SmallMoleculeDrug DB00857 Terbinafine Thumb
4 Approved SmallMoleculeDrug DB00735 Naftifine Thumb
5 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb

20 predicted interactions (drugs) of input target (SQLE): Squalene monooxygenase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb 29.0%
2 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb 26.1%
3 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 24.5%
4 Approved SmallMoleculeDrug DB01194 Brinzolamide Thumb 22.5%
5 Approved;
SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb 20.7%
6 Withdrawn SmallMoleculeDrug DB00311 Ethoxzolamide Thumb 20.5%
7 Approved;
Vet approved
SmallMoleculeDrug DB00819 Acetazolamide Thumb 20.4%
8 Experimental SmallMoleculeDrug DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Thumb 20.2%
9 Investigational;
SmallMoleculeDrug DB00197 Troglitazone Thumb 19.1%
10 Approved;
SmallMoleculeDrug DB01144 Diclofenamide Thumb 19.0%
11 Approved SmallMoleculeDrug DB00562 Benzthiazide Thumb 19.0%
12 Experimental SmallMoleculeDrug DB08437 Puromycin Thumb 18.8%
13 Approved;
SmallMoleculeDrug DB12965 Silver Thumb 18.8%
14 Approved SmallMoleculeDrug DB09460 Sodium carbonate Thumb 18.6%
15 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 18.5%
16 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 18.5%
17 Experimental SmallMoleculeDrug DB07557 (5BETA)-PREGNANE-3,20-DIONE Thumb 17.8%
18 Experimental SmallMoleculeDrug DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Thumb 17.7%
19 Investigational SmallMoleculeDrug DB12418 Saccharin Thumb 17.5%
20 Approved SmallMoleculeDrug DB00703 Methazolamide Thumb 17.1%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.