QuartataWeb 1.0

5 known interactions (drugs) of input target (SQLE): Squalene monooxygenase

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Approved	SmallMoleculeDrug	DB01091	Butenafine	CN(CC1=CC=C(C=C1)C(C)(C)C)CC1=CC=CC2=CC=CC=C12
2	Investigational	SmallMoleculeDrug	DB04927	NM100060	NA
3	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB00857	Terbinafine	CN(C\C=C\C#CC(C)(C)C)CC1=CC=CC2=CC=CC=C12
4	Approved	SmallMoleculeDrug	DB00735	Naftifine	CN(CC=CC1=CC=CC=C1)CC1=CC=CC2=CC=CC=C12
5	Investigational	SmallMoleculeDrug	DB08846	Ellagic Acid	OC1=C(O)C2=C3C(=C1)C(=O)OC1=C3C(=CC(O)=C1O)C(=O)O2

20 predicted interactions (drugs) of input target (SQLE): Squalene monooxygenase

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Approved; Investigational	SmallMoleculeDrug	DB00909	Zonisamide	NS(=O)(=O)CC1=NOC2=CC=CC=C12	29.0%
2	Experimental	SmallMoleculeDrug	DB01812	Adenosine-3'-5'-Diphosphate	NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O	26.1%
3	Approved	SmallMoleculeDrug	DB00273	Topiramate	[H][C@@]12CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@@]3([H])[C@]1([H])OC(C)(C)O2	24.5%
4	Approved	SmallMoleculeDrug	DB01194	Brinzolamide	CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S2)S(N)(=O)=O	22.5%
5	Approved; Investigational	SmallMoleculeDrug	DB02325	Isopropyl Alcohol	CC(C)O	20.7%
6	Withdrawn	SmallMoleculeDrug	DB00311	Ethoxzolamide	CCOC1=CC2=C(C=C1)N=C(S2)S(N)(=O)=O	20.5%
7	Approved; Vet approved	SmallMoleculeDrug	DB00819	Acetazolamide	CC(=O)NC1=NN=C(S1)S(N)(=O)=O	20.4%
8	Experimental	SmallMoleculeDrug	DB02494	Alpha-Hydroxy-Beta-Phenyl-Propionic Acid	[H][C@](O)(CC1=CC=CC=C1)C(O)=O	20.2%
9	Investigational; Withdrawn	SmallMoleculeDrug	DB00197	Troglitazone	CC1=C(C)C2=C(CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)O2)C(C)=C1O	19.1%
10	Approved; Investigational	SmallMoleculeDrug	DB01144	Diclofenamide	NS(=O)(=O)C1=CC(=C(Cl)C(Cl)=C1)S(N)(=O)=O	19.0%
11	Approved	SmallMoleculeDrug	DB00562	Benzthiazide	NS(=O)(=O)C1=C(Cl)C=C2NC(CSCC3=CC=CC=C3)=NS(=O)(=O)C2=C1	19.0%
12	Experimental	SmallMoleculeDrug	DB08437	Puromycin	[H][C@](N)(CC1=CC=C(OC)C=C1)C(=O)N[C@]1([H])[C@@]([H])(CO)O[C@@]([H])(N2C=NC3=C(N=CN=C23)N(C)C)[C@]1([H])O	18.8%
13	Approved; Investigational	SmallMoleculeDrug	DB12965	Silver	[Ag]	18.8%
14	Approved	SmallMoleculeDrug	DB09460	Sodium carbonate	[Na+].[Na+].[O-]C([O-])=O	18.6%
15	Approved	SmallMoleculeDrug	DB00381	Amlodipine	CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC	18.5%
16	Approved	SmallMoleculeDrug	DB00898	Ethanol	CCO	18.5%
17	Experimental	SmallMoleculeDrug	DB07557	(5BETA)-PREGNANE-3,20-DIONE	[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(C)=O	17.8%
18	Experimental	SmallMoleculeDrug	DB08515	(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE	[H][C@](O)([C@@]1([H])CCCC=C1)[C@]1(NC(=O)[C@]2([H])CCO[C@]12C)C=O	17.7%
19	Investigational	SmallMoleculeDrug	DB12418	Saccharin	O=C1NS(=O)(=O)C2=C1C=CC=C2	17.5%
20	Approved	SmallMoleculeDrug	DB00703	Methazolamide	CN1N=C(SC1=NC(C)=O)S(N)(=O)=O	17.1%