QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P31995
No. Gene UniProt ID Protein Name Pathway PDB
1 FCGR2C P31995 Low affinity immunoglobulin gamma Fc region receptor II-c hsa04145; hsa04380; hsa05140; hsa05150; hsa05152 3WJL


19 known interactions (drugs) of input target (FCGR2C): Low affinity immunoglobulin gamma Fc region receptor II-c
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 BiotechDrug DB00074 Basiliximab Thumb
2 Approved;
Investigational		 BiotechDrug DB00095 Efalizumab Thumb
3 Approved;
Investigational		 BiotechDrug DB00072 Trastuzumab Thumb
4 Approved;
Investigational		 BiotechDrug DB00081 Tositumomab Thumb
5 Approved;
Investigational		 BiotechDrug DB00112 Bevacizumab Thumb
6 Approved;
Investigational		 BiotechDrug DB00087 Alemtuzumab Thumb
7 Approved;
Investigational		 BiotechDrug DB00056 Gemtuzumab ozogamicin Thumb
8 Approved BiotechDrug DB00002 Cetuximab Thumb
9 Approved BiotechDrug DB00054 Abciximab Thumb
10 Approved BiotechDrug DB00051 Adalimumab Thumb
11 Approved;
Investigational		 BiotechDrug DB00028 Immune Globulin Human Thumb
12 Approved;
Investigational;
Withdrawn		 BiotechDrug DB00092 Alefacept Thumb
13 Approved;
Investigational		 BiotechDrug DB00108 Natalizumab Thumb
14 Approved;
Investigational		 BiotechDrug DB00110 Palivizumab Thumb
15 Approved;
Investigational		 BiotechDrug DB00078 Ibritumomab tiuxetan Thumb
16 Approved;
Investigational		 BiotechDrug DB00005 Etanercept Thumb
17 Approved;
Investigational		 BiotechDrug DB00075 Muromonab Thumb
18 Investigational;
Withdrawn		 BiotechDrug DB00111 Daclizumab Thumb
19 Approved BiotechDrug DB00073 Rituximab Thumb


20 predicted interactions (drugs) of input target (FCGR2C): Low affinity immunoglobulin gamma Fc region receptor II-c
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 BiotechDrug DB11767 Sarilumab Thumb 73.8%
2 Approved;
Investigational;
Withdrawn		 BiotechDrug DB06607 Catumaxomab Thumb 71.5%
3 Approved;
Investigational		 SmallMoleculeDrug DB00992 Methyl aminolevulinate Thumb 48.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB00707 Porfimer sodium Thumb 47.9%
5 Approved;
Investigational		 BiotechDrug DB12023 Benralizumab Thumb 42.6%
6 Approved BiotechDrug DB00098 Antithymocyte immunoglobulin (rabbit) Thumb 33.8%
7 Experimental SmallMoleculeDrug DB02371 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Thumb 32.7%
8 Approved;
Investigational		 BiotechDrug DB09228 Conestat alfa Thumb 31.7%
9 Approved BiotechDrug DB06404 Human C1-esterase inhibitor Thumb 31.2%
10 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 26.0%
11 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 23.7%
12 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb 19.9%
13 Approved;
Investigational		 BiotechDrug DB11988 Ocrelizumab Thumb 18.4%
14 Experimental SmallMoleculeDrug DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Thumb 17.9%
15 Experimental SmallMoleculeDrug DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Thumb 17.4%
16 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 17.2%
17 Approved;
Investigational		 BiotechDrug DB00004 Denileukin diftitox Thumb 17.0%
18 Approved BiotechDrug DB00041 Aldesleukin Thumb 16.8%
19 Approved;
Investigational		 SmallMoleculeDrug DB00357 Aminoglutethimide Thumb 16.5%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB00160 L-Alanine Thumb 16.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.