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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P29317
No. Gene UniProt ID Protein Name Pathway PDB
1 EPHA2 P29317 Ephrin type-A receptor 2 hsa04010; hsa04014; hsa04015; hsa04151; hsa04360 1MQB; 2E8N; 2K9Y; 2KSO; 2X10; 2X11; 3C8X; 3CZU; 3FL7; 3HEI; 3HPN; 3KKA; 3MBW; 3MX0; 3SKJ; 4P2K; 4PDO; 4TRL

4 known interactions (drugs) of input target (EPHA2): Ephrin type-A receptor 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
3 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb
4 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb

20 predicted interactions (drugs) of input target (EPHA2): Ephrin type-A receptor 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 42.9%
2 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 34.6%
3 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 34.6%
4 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 32.9%
5 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 32.4%
6 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 27.6%
7 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 27.3%
8 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 26.9%
9 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 25.6%
10 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 25.1%
11 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 23.9%
12 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb 23.6%
13 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 22.5%
14 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 22.5%
15 Experimental SmallMoleculeDrug DB01962 Phosphonotyrosine Thumb 22.1%
16 Investigational SmallMoleculeDrug DB05184 XL228 Thumb 21.9%
17 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 21.8%
18 Investigational SmallMoleculeDrug DB05157 KC706 Thumb 21.0%
19 Approved;
SmallMoleculeDrug DB08875 Cabozantinib Thumb 20.7%
20 Approved;
SmallMoleculeDrug DB04868 Nilotinib Thumb 20.0%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.