QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P42685
No. Gene UniProt ID Protein Name Pathway PDB
1 FRK P42685 Tyrosine-protein kinase FRK NA NA


3 known interactions (drugs) of input target (FRK): Tyrosine-protein kinase FRK
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb


20 predicted interactions (drugs) of input target (FRK): Tyrosine-protein kinase FRK
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb 45.1%
2 Approved;
Investigational		 SmallMoleculeDrug DB00398 Sorafenib Thumb 35.6%
3 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 34.6%
4 Approved;
Investigational		 SmallMoleculeDrug DB01268 Sunitinib Thumb 32.0%
5 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 31.7%
6 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 31.3%
7 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 31.1%
8 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 29.9%
9 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 25.2%
10 Approved;
Investigational		 SmallMoleculeDrug DB06595 Midostaurin Thumb 25.0%
11 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 24.4%
12 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 24.0%
13 Approved;
Investigational		 SmallMoleculeDrug DB09078 Lenvatinib Thumb 23.8%
14 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 23.2%
15 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 22.9%
16 Experimental SmallMoleculeDrug DB01962 Phosphonotyrosine Thumb 21.9%
17 Investigational SmallMoleculeDrug DB05075 TG-100801 Thumb 21.8%
18 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 21.6%
19 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 21.0%
20 Approved;
Investigational		 SmallMoleculeDrug DB04868 Nilotinib Thumb 20.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.