QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q05655
No. Gene UniProt ID Protein Name Pathway PDB
1 PRKCD Q05655 Protein kinase C delta type hsa04062; hsa04140; hsa04270; hsa04621; hsa04625; hsa04666; hsa04722; hsa04750; hsa04912; hsa04915; hsa04930; hsa04931; hsa04933 1YRK; 2YUU


4 known interactions (drugs) of input target (PRKCD): Protein kinase C delta type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
3 Approved SmallMoleculeDrug DB05013 Ingenol Mebutate Thumb
4 Experimental SmallMoleculeDrug DB04376 13-Acetylphorbol Thumb


20 predicted interactions (drugs) of input target (PRKCD): Protein kinase C delta type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 33.7%
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 28.5%
3 Approved;
Investigational		 SmallMoleculeDrug DB06595 Midostaurin Thumb 23.1%
4 Experimental SmallMoleculeDrug DB02482 Phosphonothreonine Thumb 21.2%
5 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb 19.1%
6 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00141 N-Acetylglucosamine Thumb 18.8%
7 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb 18.1%
8 Investigational SmallMoleculeDrug DB06451 Aprinocarsen Thumb 17.9%
9 Approved SmallMoleculeDrug DB00594 Amiloride Thumb 17.4%
10 Approved SmallMoleculeDrug DB11605 Myrrh Thumb 17.2%
11 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 17.1%
12 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 16.6%
13 Approved;
Nutraceutical		 SmallMoleculeDrug DB00139 Succinic acid Thumb 16.5%
14 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 16.5%
15 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 16.4%
16 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 16.2%
17 Approved;
Nutraceutical		 SmallMoleculeDrug DB00168 Aspartame Thumb 16.1%
18 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 16.1%
19 Experimental SmallMoleculeDrug DB03814 2-(N-Morpholino)-Ethanesulfonic Acid Thumb 15.9%
20 Experimental SmallMoleculeDrug DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose Thumb 15.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.