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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q15125
No. Gene UniProt ID Protein Name Pathway PDB
1 EBP Q15125 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase hsa00100; hsa01100 NA


1 known interactions (drugs) of input target (EBP): 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb


20 predicted interactions (drugs) of input target (EBP): 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB05013 Ingenol Mebutate Thumb 18.5%
2 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 18.3%
3 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00163 Vitamin E Thumb 17.3%
4 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 17.2%
5 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 16.3%
6 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 15.0%
7 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 14.9%
8 Experimental SmallMoleculeDrug DB03777 Rbt205 Inhibitor Thumb 14.6%
9 Experimental SmallMoleculeDrug DB06884 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE Thumb 14.5%
10 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 14.3%
11 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb 14.3%
12 Approved;
Withdrawn		 SmallMoleculeDrug DB00637 Astemizole Thumb 14.2%
13 Approved;
Investigational		 SmallMoleculeDrug DB00367 Levonorgestrel Thumb 13.7%
14 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00141 N-Acetylglucosamine Thumb 13.5%
15 Investigational SmallMoleculeDrug DB04468 Afimoxifene Thumb 13.4%
16 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB14001 alpha-Tocopherol succinate Thumb 13.4%
17 Approved;
Investigational		 SmallMoleculeDrug DB00255 Diethylstilbestrol Thumb 13.3%
18 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB14002 D-alpha-Tocopherol acetate Thumb 13.2%
19 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 12.8%
20 Approved;
Investigational		 SmallMoleculeDrug DB01026 Ketoconazole Thumb 12.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.