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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q15078
No. Gene UniProt ID Protein Name Pathway PDB
1 CDK5R1 Q15078 Cyclin-dependent kinase 5 activator 1 hsa05010; hsa05030 1H4L; 1UNG; 1UNH; 1UNL; 3O0G


2 known interactions (drugs) of input target (CDK5R1): Cyclin-dependent kinase 5 activator 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB07364 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE Thumb
2 Experimental SmallMoleculeDrug DB02052 Indirubin-3'-Monoxime Thumb


20 predicted interactions (drugs) of input target (CDK5R1): Cyclin-dependent kinase 5 activator 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB04014 Alsterpaullone Thumb 33.4%
2 Experimental;
Investigational		 SmallMoleculeDrug DB03496 Alvocidib Thumb 31.6%
3 Experimental SmallMoleculeDrug DB03428 SU9516 Thumb 29.6%
4 Experimental SmallMoleculeDrug DB02950 Hymenialdisine Thumb 27.0%
5 Experimental SmallMoleculeDrug DB02116 Olomoucine Thumb 25.0%
6 Experimental SmallMoleculeDrug DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Thumb 22.9%
7 Investigational SmallMoleculeDrug DB05037 AT7519 Thumb 20.9%
8 Experimental SmallMoleculeDrug DB02482 Phosphonothreonine Thumb 20.0%
9 Investigational SmallMoleculeDrug DB06195 Seliciclib Thumb 19.3%
10 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01234 Dexamethasone Thumb 18.6%
11 Approved;
Experimental		 SmallMoleculeDrug DB03017 Lauric Acid Thumb 18.3%
12 Experimental SmallMoleculeDrug DB02733 Purvalanol Thumb 17.1%
13 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 17.1%
14 Approved;
Investigational		 SmallMoleculeDrug DB08889 Carfilzomib Thumb 17.0%
15 Experimental SmallMoleculeDrug DB04400 L-erythro-7,8-dihydrobiopterin Thumb 16.6%
16 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb 16.3%
17 Approved;
Investigational		 BiotechDrug DB00087 Alemtuzumab Thumb 16.0%
18 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 15.8%
19 Approved SmallMoleculeDrug DB00201 Caffeine Thumb 14.3%
20 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 14.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.