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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P60568
No. Gene UniProt ID Protein Name Pathway PDB
1 IL2 P60568 Interleukin-2 hsa04060; hsa04151; hsa04625; hsa04630; hsa04658; hsa04659; hsa04660; hsa04672; hsa04940; hsa05142; hsa05162; hsa05166; hsa05200; hsa05320; hsa05321; hsa05330; hsa05332

13 known interactions (drugs) of input target (IL2): Interleukin-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB03957 SP2456 Thumb
2 Approved;
SmallMoleculeDrug DB05676 Apremilast Thumb
3 Experimental SmallMoleculeDrug DB02555 SP4160 Thumb
4 Approved;
BiotechDrug DB05299 keyhole limpet hemocyanin Thumb
5 Investigational SmallMoleculeDrug DB06083 Tapinarof Thumb
6 Experimental SmallMoleculeDrug DB03372 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One Thumb
7 Experimental SmallMoleculeDrug DB03455 (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid Thumb
8 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb
9 Approved SmallMoleculeDrug DB01327 Cefazolin Thumb
10 Investigational SmallMoleculeDrug DB05304 WX-G250 Thumb
11 Experimental SmallMoleculeDrug DB03453 (R)—N[2-[1-(aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-l-phenylalanine methylester Thumb
12 Experimental SmallMoleculeDrug DB02581 5-[2,3-Dichloro-4-(5-{1-[2-(2-Guanidino-4-Methyl-Pentanoylamino)-Acetyl]-Piperidin-4-Yl}-1-Methyl-1h-Pyrazol-3-Yl)-Phenoxymethyl]-Furan-2-Carboxylic Acid Thumb
13 Experimental SmallMoleculeDrug DB04278 2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide Thumb

20 predicted interactions (drugs) of input target (IL2): Interleukin-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 31.7%
2 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 27.3%
3 Approved;
SmallMoleculeDrug DB00144 Phosphatidyl serine Thumb 26.5%
4 Approved;
Vet approved
SmallMoleculeDrug DB08818 Hyaluronic acid Thumb 23.4%
5 Approved;
SmallMoleculeDrug DB03247 Flavin mononucleotide Thumb 22.4%
6 Investigational SmallMoleculeDrug DB05767 Andrographolide Thumb 22.1%
7 Approved;
SmallMoleculeDrug DB01136 Carvedilol Thumb 21.2%
8 Approved;
SmallMoleculeDrug DB01576 Dextroamphetamine Thumb 21.1%
9 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 21.1%
10 Approved SmallMoleculeDrug DB00862 Vardenafil Thumb 21.0%
11 Approved BiotechDrug DB11311 Prothrombin Thumb 20.8%
12 Approved SmallMoleculeDrug DB00630 Alendronic acid Thumb 20.7%
13 Experimental SmallMoleculeDrug DB08373 4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL Thumb 20.7%
14 Experimental SmallMoleculeDrug DB08378 4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID Thumb 20.6%
15 Approved;
Vet approved
SmallMoleculeDrug DB01392 Yohimbine Thumb 20.5%
16 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 20.4%
17 Approved;
SmallMoleculeDrug DB01411 Pranlukast Thumb 20.3%
18 Approved;
SmallMoleculeDrug DB01577 Methamphetamine Thumb 20.1%
19 Approved;
SmallMoleculeDrug DB01579 Phendimetrazine Thumb 19.6%
20 Approved;
BiotechDrug DB09036 Siltuximab Thumb 19.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.