QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O60931
No. Gene UniProt ID Protein Name Pathway PDB
1 CTNS O60931 Cystinosin hsa04142 NA


1 known interactions (drugs) of input target (CTNS): Cystinosin
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00138 Cystine Thumb


20 predicted interactions (drugs) of input target (CTNS): Cystinosin
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 18.4%
2 Approved SmallMoleculeDrug DB00825 Menthol Thumb 15.8%
3 Experimental SmallMoleculeDrug DB07664 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE Thumb 14.0%
4 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 13.8%
5 Approved;
Investigational		 SmallMoleculeDrug DB00740 Riluzole Thumb 13.5%
6 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 13.3%
7 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 12.7%
8 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 12.4%
9 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb 11.6%
10 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 11.5%
11 Experimental SmallMoleculeDrug DB07929 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE Thumb 11.2%
12 Approved;
Nutraceutical		 SmallMoleculeDrug DB00129 Ornithine Thumb 11.2%
13 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 10.9%
14 Investigational SmallMoleculeDrug DB05540 Alanosine Thumb 10.8%
15 Approved BiotechDrug DB00098 Antithymocyte immunoglobulin (rabbit) Thumb 10.8%
16 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 10.8%
17 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb 10.6%
18 Experimental SmallMoleculeDrug DB03245 S-4-Nitrobutyryl-Coa Thumb 10.5%
19 Experimental SmallMoleculeDrug DB04147 Lauryl Dimethylamine-N-Oxide Thumb 10.5%
20 Approved;
Investigational		 SmallMoleculeDrug DB00528 Lercanidipine Thumb 10.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.