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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P22455
No. Gene UniProt ID Protein Name Pathway PDB
1 FGFR4 P22455 Fibroblast growth factor receptor 4 hsa04010; hsa04014; hsa04015; hsa04144; hsa04151; hsa04550; hsa04810; hsa05200 1QCT; 4QQ5; 4QQC; 4QQJ; 4QQT; 4QRC; 4R6V; 4TYE; 4TYG; 4TYI; 4TYJ; 4UXQ; 4XCU


4 known interactions (drugs) of input target (FGFR4): Fibroblast growth factor receptor 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB08901 Ponatinib Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB01109 Heparin Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB09078 Lenvatinib Thumb
4 Approved BiotechDrug DB00039 Palifermin Thumb


20 predicted interactions (drugs) of input target (FGFR4): Fibroblast growth factor receptor 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB12010 Fostamatinib Thumb 62.7%
2 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 47.2%
3 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 45.6%
4 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 43.6%
5 Experimental SmallMoleculeDrug DB02058 SU4984 Thumb 42.0%
6 Approved;
Investigational
SmallMoleculeDrug DB00398 Sorafenib Thumb 38.5%
7 Approved;
Investigational
SmallMoleculeDrug DB01254 Dasatinib Thumb 38.0%
8 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 35.5%
9 Experimental SmallMoleculeDrug DB02491 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Thumb 32.5%
10 Approved;
Nutraceutical;
Vet approved
SmallMoleculeDrug DB00162 Vitamin A Thumb 30.5%
11 Experimental SmallMoleculeDrug DB07840 (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol Thumb 30.3%
12 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 30.0%
13 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 29.9%
14 Approved;
Investigational
SmallMoleculeDrug DB06595 Midostaurin Thumb 29.9%
15 Experimental SmallMoleculeDrug DB08577 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE Thumb 28.1%
16 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 27.5%
17 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 26.2%
18 Approved;
Investigational
SmallMoleculeDrug DB01268 Sunitinib Thumb 25.8%
19 Approved;
Investigational
SmallMoleculeDrug DB04868 Nilotinib Thumb 25.0%
20 Experimental SmallMoleculeDrug DB07525 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine Thumb 24.5%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.