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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P04083
No. Gene UniProt ID Protein Name Pathway PDB
1 ANXA1 P04083 Annexin A1 NA 1AIN; 1BO9; 1QLS


3 known interactions (drugs) of input target (ANXA1): Annexin A1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01234 Dexamethasone Thumb
2 Approved SmallMoleculeDrug DB00288 Amcinonide Thumb
3 Approved;
Vet approved		 SmallMoleculeDrug DB00741 Hydrocortisone Thumb


20 predicted interactions (drugs) of input target (ANXA1): Annexin A1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00223 Diflorasone Thumb 21.2%
2 Approved BiotechDrug DB00071 Insulin Pork Thumb 19.8%
3 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09095 Difluocortolone Thumb 19.3%
4 Investigational SmallMoleculeDrug DB13003 Cortivazol Thumb 18.6%
5 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 18.4%
6 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 18.4%
7 Approved;
Investigational		 SmallMoleculeDrug DB00834 Mifepristone Thumb 18.4%
8 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb 18.4%
9 Approved;
Illicit		 SmallMoleculeDrug DB01185 Fluoxymesterone Thumb 18.2%
10 Experimental SmallMoleculeDrug DB07853 [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE Thumb 18.2%
11 Approved;
Vet approved		 SmallMoleculeDrug DB00620 Triamcinolone Thumb 17.7%
12 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 17.5%
13 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00591 Fluocinolone Acetonide Thumb 17.0%
14 Approved;
Investigational		 SmallMoleculeDrug DB01047 Fluocinonide Thumb 16.9%
15 Approved SmallMoleculeDrug DB00547 Desoximetasone Thumb 16.7%
16 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 16.6%
17 Approved;
Vet approved		 SmallMoleculeDrug DB00663 Flumethasone Thumb 16.5%
18 Experimental;
Illicit		 SmallMoleculeDrug DB01569 Formebolone Thumb 16.4%
19 Experimental;
Investigational		 SmallMoleculeDrug DB04630 Aldosterone Thumb 16.4%
20 Approved;
Investigational		 BiotechDrug DB00030 Insulin Human Thumb 16.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.