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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P23416
No. Gene UniProt ID Protein Name Pathway PDB
1 GLRA2 P23416 Glycine receptor subunit alpha-2 hsa04080 NA


5 known interactions (drugs) of input target (GLRA2): Glycine receptor subunit alpha-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb
2 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb
4 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb
5 Approved SmallMoleculeDrug DB00898 Ethanol Thumb


20 predicted interactions (drugs) of input target (GLRA2): Glycine receptor subunit alpha-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb 53.8%
2 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 51.9%
3 Approved;
Investigational		 SmallMoleculeDrug DB11582 Thiocolchicoside Thumb 50.9%
4 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 49.1%
5 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 48.9%
6 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb 48.6%
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb 48.4%
8 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00602 Ivermectin Thumb 47.1%
9 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 45.2%
10 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 44.7%
11 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb 44.4%
12 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb 44.2%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb 44.1%
14 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 43.8%
15 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb 43.8%
16 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb 43.8%
17 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb 43.7%
18 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01558 Bromazepam Thumb 43.7%
19 Approved;
Illicit		 SmallMoleculeDrug DB00349 Clobazam Thumb 43.1%
20 Approved SmallMoleculeDrug DB01189 Desflurane Thumb 43.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.