QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9UGM1
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRNA9 Q9UGM1 Neuronal acetylcholine receptor subunit alpha-9 hsa04080 4D01; 4UXU; 4UY2


7 known interactions (drugs) of input target (CHRNA9): Neuronal acetylcholine receptor subunit alpha-9
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB05069 ATG003 Thumb
2 Approved SmallMoleculeDrug DB00674 Galantamine Thumb
3 Investigational SmallMoleculeDrug DB05137 Lobeline Thumb
4 Experimental;
Investigational		 SmallMoleculeDrug DB08837 Tetraethylammonium Thumb
5 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
6 Investigational SmallMoleculeDrug DB05740 RPI-78M Thumb
7 Approved SmallMoleculeDrug DB00184 Nicotine Thumb


20 predicted interactions (drugs) of input target (CHRNA9): Neuronal acetylcholine receptor subunit alpha-9
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB01090 Pentolinium Thumb 46.2%
2 Approved;
Investigational		 SmallMoleculeDrug DB09028 Cytisine Thumb 44.6%
3 Experimental SmallMoleculeDrug DB07720 Epibatidine Thumb 39.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB00657 Mecamylamine Thumb 36.0%
5 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb 35.9%
6 Approved;
Investigational		 SmallMoleculeDrug DB01116 Trimethaphan Thumb 35.8%
7 Approved;
Investigational		 SmallMoleculeDrug DB01273 Varenicline Thumb 34.7%
8 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb 34.6%
9 Approved SmallMoleculeDrug DB00333 Methadone Thumb 33.1%
10 Approved SmallMoleculeDrug DB00202 Succinylcholine Thumb 32.6%
11 Approved SmallMoleculeDrug DB00915 Amantadine Thumb 30.6%
12 Approved;
Vet approved		 SmallMoleculeDrug DB00472 Fluoxetine Thumb 27.2%
13 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb 26.4%
14 Approved;
Investigational		 SmallMoleculeDrug DB00981 Physostigmine Thumb 25.2%
15 Approved SmallMoleculeDrug DB01245 Decamethonium Thumb 24.9%
16 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb 24.8%
17 Approved;
Investigational		 SmallMoleculeDrug DB00564 Carbamazepine Thumb 24.3%
18 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb 24.3%
19 Approved;
Nutraceutical		 SmallMoleculeDrug DB00138 Cystine Thumb 23.7%
20 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb 23.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.