Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics


Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q04759
No. Gene UniProt ID Protein Name Pathway PDB
1 PRKCQ Q04759 Protein kinase C theta type hsa04064; hsa04140; hsa04270; hsa04658; hsa04659; hsa04660; hsa04750; hsa04920; hsa04931; hsa05162 1XJD; 2ENJ; 2ENN; 2ENZ; 2JED; 4Q9Z; 4RA5

5 known interactions (drugs) of input target (PRKCQ): Protein kinase C theta type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB02482 Phosphonothreonine Thumb
2 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb
3 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
4 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb
5 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb

20 predicted interactions (drugs) of input target (PRKCQ): Protein kinase C theta type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 30.4%
2 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 28.9%
3 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 28.5%
4 Experimental;
SmallMoleculeDrug DB03496 Alvocidib Thumb 25.5%
5 Experimental SmallMoleculeDrug DB03777 Rbt205 Inhibitor Thumb 24.5%
6 Experimental;
SmallMoleculeDrug DB03366 Imidazole Thumb 23.0%
7 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 22.1%
8 Approved;
SmallMoleculeDrug DB00119 Pyruvic acid Thumb 21.3%
9 Approved;
Vet approved
SmallMoleculeDrug DB14002 D-alpha-Tocopherol acetate Thumb 20.1%
10 Investigational SmallMoleculeDrug DB05169 AT9283 Thumb 18.2%
11 Approved SmallMoleculeDrug DB05013 Ingenol Mebutate Thumb 17.6%
12 Approved;
Vet approved
SmallMoleculeDrug DB00281 Lidocaine Thumb 17.4%
13 Experimental SmallMoleculeDrug DB04079 Heptane-1,2,3-Triol Thumb 17.4%
14 Experimental SmallMoleculeDrug DB02052 Indirubin-3'-Monoxime Thumb 17.2%
15 Experimental SmallMoleculeDrug DB07242 (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Thumb 17.1%
16 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 16.9%
17 Experimental SmallMoleculeDrug DB01754 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Thumb 16.7%
18 Experimental;
SmallMoleculeDrug DB04216 Quercetin Thumb 16.3%
19 Investigational;
SmallMoleculeDrug DB00171 ATP Thumb 16.2%
20 Experimental SmallMoleculeDrug DB01728 3-[Aminoethylphosphoryl]-[1,2-Di-Palmitoyl]-Sn-Glycerol Thumb 16.2%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.