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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P17787
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRNB2 P17787 Neuronal acetylcholine receptor subunit beta-2 hsa04080; hsa04725; hsa05033 2GVT; 2K58; 2K59; 2KSR; 2LM2


17 known interactions (drugs) of input target (CHRNB2): Neuronal acetylcholine receptor subunit beta-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
2 Experimental SmallMoleculeDrug DB07720 Epibatidine Thumb
3 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb
4 Investigational SmallMoleculeDrug DB05458 Pozanicline Thumb
5 Approved SmallMoleculeDrug DB00674 Galantamine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00747 Scopolamine Thumb
7 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00657 Mecamylamine Thumb
9 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb
10 Investigational SmallMoleculeDrug DB05740 RPI-78M Thumb
11 Approved SmallMoleculeDrug DB01245 Decamethonium Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB00981 Physostigmine Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB09028 Cytisine Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB01273 Varenicline Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB00564 Carbamazepine Thumb
16 Investigational SmallMoleculeDrug DB05855 Rivanicline Thumb
17 Approved SmallMoleculeDrug DB00184 Nicotine Thumb


20 predicted interactions (drugs) of input target (CHRNB2): Neuronal acetylcholine receptor subunit beta-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00915 Amantadine Thumb 64.6%
2 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb 51.4%
3 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb 50.5%
4 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb 49.1%
5 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb 48.8%
6 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb 48.0%
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 47.8%
8 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 47.4%
9 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 47.3%
10 Approved SmallMoleculeDrug DB01354 Heptabarbital Thumb 46.8%
11 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb 45.3%
12 Approved;
Vet approved		 SmallMoleculeDrug DB00472 Fluoxetine Thumb 45.1%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb 45.0%
14 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13953 Estradiol benzoate Thumb 43.9%
15 Investigational SmallMoleculeDrug DB05137 Lobeline Thumb 43.6%
16 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb 43.5%
17 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00783 Estradiol Thumb 43.5%
18 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13955 Estradiol dienanthate Thumb 43.4%
19 Approved;
Investigational		 SmallMoleculeDrug DB01227 Levomethadyl Acetate Thumb 42.7%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb 42.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.