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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P01579
No. Gene UniProt ID Protein Name Pathway PDB
1 IFNG P01579 Interferon gamma hsa03050; hsa04060; hsa04066; hsa04217; hsa04350; hsa04380; hsa04612; hsa04630; hsa04650; hsa04657; hsa04658; hsa04659; hsa04660; hsa04940; hsa05132; hsa05140; hsa05142; hsa05143; hsa05144; hsa05145; hsa05146; hsa05152; hsa05162; hsa05164; hsa05168; hsa05169; hsa05200; hsa05321; hsa05322; hsa05323; hsa05330; hsa05332; hsa05418 1EKU; 1FG9; 1FYH; 1HIG; 3BES

7 known interactions (drugs) of input target (IFNG): Interferon gamma
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb
2 Approved;
SmallMoleculeDrug DB05676 Apremilast Thumb
3 Approved;
SmallMoleculeDrug DB01296 Glucosamine Thumb
4 Approved SmallMoleculeDrug DB01250 Olsalazine Thumb
5 Investigational BiotechDrug DB05111 Fontolizumab Thumb
6 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb
7 Investigational BiotechDrug DB05110 VIR201 Thumb

20 predicted interactions (drugs) of input target (IFNG): Interferon gamma
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational SmallMoleculeDrug DB05767 Andrographolide Thumb 29.6%
2 Approved SmallMoleculeDrug DB00201 Caffeine Thumb 28.6%
3 Approved BiotechDrug DB00051 Adalimumab Thumb 28.5%
4 Approved;
SmallMoleculeDrug DB11967 Binimetinib Thumb 28.4%
5 Investigational SmallMoleculeDrug DB05869 Ethyl pyruvate Thumb 28.1%
6 Approved;
SmallMoleculeDrug DB09462 Glycerin Thumb 25.0%
7 Investigational SmallMoleculeDrug DB12140 Dilmapimod Thumb 24.4%
8 Investigational SmallMoleculeDrug DB05968 PR-104 Thumb 24.2%
9 Investigational SmallMoleculeDrug DB05513 Atiprimod Thumb 23.7%
10 Experimental SmallMoleculeDrug DB01901 Sucrosofate Thumb 23.5%
11 Investigational SmallMoleculeDrug DB05470 VX-702 Thumb 23.3%
12 Investigational SmallMoleculeDrug DB05017 YSIL6 Thumb 23.2%
13 Approved;
SmallMoleculeDrug DB13751 Glycyrrhizic acid Thumb 22.8%
14 Investigational SmallMoleculeDrug DB05744 CRx-139 Thumb 22.5%
15 Approved SmallMoleculeDrug DB11093 Calcium Citrate Thumb 22.4%
16 Approved;
BiotechDrug DB00072 Trastuzumab Thumb 21.9%
17 Approved SmallMoleculeDrug DB00768 Olopatadine Thumb 21.8%
18 Approved;
SmallMoleculeDrug DB01017 Minocycline Thumb 21.7%
19 Approved SmallMoleculeDrug DB08910 Pomalidomide Thumb 21.0%
20 Approved;
Vet approved
SmallMoleculeDrug DB00668 Epinephrine Thumb 20.6%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.