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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P04155
No. Gene UniProt ID Protein Name Pathway PDB
1 TFF1 P04155 Trefoil factor 1 hsa04915 1HI7; 1PS2


2 known interactions (drugs) of input target (TFF1): Trefoil factor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational
SmallMoleculeDrug DB00481 Raloxifene Thumb
2 Investigational SmallMoleculeDrug DB04468 Afimoxifene Thumb


20 predicted interactions (drugs) of input target (TFF1): Trefoil factor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Investigational
SmallMoleculeDrug DB00255 Diethylstilbestrol Thumb 32.6%
2 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 28.9%
3 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB13954 Estradiol cypionate Thumb 27.2%
4 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00783 Estradiol Thumb 25.6%
5 Investigational SmallMoleculeDrug DB01645 Genistein Thumb 25.6%
6 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB13953 Estradiol benzoate Thumb 25.1%
7 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB13955 Estradiol dienanthate Thumb 25.0%
8 Approved;
Vet approved
SmallMoleculeDrug DB01183 Naloxone Thumb 24.7%
9 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB13956 Estradiol valerate Thumb 23.7%
10 Approved;
Investigational
SmallMoleculeDrug DB12965 Silver Thumb 22.1%
11 Experimental;
Investigational
SmallMoleculeDrug DB04216 Quercetin Thumb 21.0%
12 Investigational SmallMoleculeDrug DB11674 Equol Thumb 20.5%
13 Investigational;
Withdrawn
SmallMoleculeDrug DB00197 Troglitazone Thumb 20.5%
14 Approved;
Investigational
SmallMoleculeDrug DB09535 Octocrylene Thumb 20.3%
15 Experimental SmallMoleculeDrug DB07032 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL Thumb 19.6%
16 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB13952 Estradiol acetate Thumb 19.6%
17 Experimental SmallMoleculeDrug DB07485 4,4'-cyclohexane-1,1-diyldiphenol Thumb 19.3%
18 Approved SmallMoleculeDrug DB00655 Estrone Thumb 19.0%
19 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB04573 Estriol Thumb 18.4%
20 Approved;
Nutraceutical;
Vet approved
SmallMoleculeDrug DB01065 Melatonin Thumb 18.2%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.