QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P24557
No. Gene UniProt ID Protein Name Pathway PDB
1 TBXAS1 P24557 Thromboxane-A synthase hsa00590; hsa01100; hsa04611 NA


4 known interactions (drugs) of input target (TBXAS1): Thromboxane-A synthase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB03052 Dazoxiben Thumb
2 Approved SmallMoleculeDrug DB00795 Sulfasalazine Thumb
3 Investigational SmallMoleculeDrug DB05505 NM-702 Thumb
4 Approved SmallMoleculeDrug DB01207 Ridogrel Thumb


20 predicted interactions (drugs) of input target (TBXAS1): Thromboxane-A synthase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB09285 Morniflumate Thumb 23.9%
2 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb 23.6%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 23.2%
4 Approved;
Investigational		 SmallMoleculeDrug DB06151 Acetylcysteine Thumb 22.9%
5 Approved;
Investigational		 SmallMoleculeDrug DB11994 Diacerein Thumb 20.2%
6 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00120 L-Phenylalanine Thumb 19.9%
7 Experimental SmallMoleculeDrug DB07384 1-ACETYL-2-CARBOXYPIPERIDINE Thumb 19.0%
8 Approved SmallMoleculeDrug DB00784 Mefenamic acid Thumb 18.8%
9 Approved SmallMoleculeDrug DB00233 Aminosalicylic Acid Thumb 18.8%
10 Approved;
Vet approved		 SmallMoleculeDrug DB00586 Diclofenac Thumb 18.5%
11 Approved;
Vet approved		 SmallMoleculeDrug DB01009 Ketoprofen Thumb 18.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb 18.1%
13 Approved SmallMoleculeDrug DB09338 Mersalyl Thumb 17.5%
14 Investigational SmallMoleculeDrug DB06521 Ertiprotafib Thumb 17.4%
15 Investigational SmallMoleculeDrug DB04725 Licofelone Thumb 16.9%
16 Experimental;
Investigational		 SmallMoleculeDrug DB04216 Quercetin Thumb 16.9%
17 Approved SmallMoleculeDrug DB06739 Seratrodast Thumb 16.3%
18 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 16.2%
19 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB13783 Acemetacin Thumb 16.2%
20 Approved BiotechDrug DB00054 Abciximab Thumb 16.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.