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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P05089
No. Gene UniProt ID Protein Name Pathway PDB
1 ARG1 P05089 Arginase-1 hsa00220; hsa00330; hsa01100; hsa01230; hsa05146

13 known interactions (drugs) of input target (ARG1): Arginase-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB04530 S,S-(2-Hydroxyethyl)Thiocysteine Thumb
2 Experimental SmallMoleculeDrug DB04648 S-propylamine-L-cysteine Thumb
3 Experimental SmallMoleculeDrug DB02499 Dinor-N(Omega)-Hydroxy-L-Arginine Thumb
4 Experimental SmallMoleculeDrug DB04585 DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID Thumb
5 Experimental SmallMoleculeDrug DB02689 S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine Thumb
6 Approved;
SmallMoleculeDrug DB06757 Manganese Thumb
7 Experimental SmallMoleculeDrug DB03731 S-2-(Boronoethyl)-L-Cysteine Thumb
8 Experimental SmallMoleculeDrug DB01983 2(S)-Amino-6-Boronohexanoic Acid Thumb
9 Approved;
SmallMoleculeDrug DB03904 Urea Thumb
10 Investigational SmallMoleculeDrug DB02381 nor-NOHA Thumb
11 Experimental SmallMoleculeDrug DB04197 Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine Thumb
12 Approved;
SmallMoleculeDrug DB00129 Ornithine Thumb
13 Experimental SmallMoleculeDrug DB03144 N-Omega-Hydroxy-L-Arginine Thumb

20 predicted interactions (drugs) of input target (ARG1): Arginase-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB12965 Silver Thumb 38.5%
2 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 32.3%
3 Approved;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb 30.6%
4 Approved SmallMoleculeDrug DB06637 Dalfampridine Thumb 27.9%
5 Approved;
SmallMoleculeDrug DB00125 L-Arginine Thumb 26.4%
6 Experimental;
SmallMoleculeDrug DB03366 Imidazole Thumb 25.3%
7 Experimental SmallMoleculeDrug DB04214 4-Nitrophenyl Phosphate Thumb 23.3%
8 Approved;
SmallMoleculeDrug DB00123 L-Lysine Thumb 22.0%
9 Approved;
SmallMoleculeDrug DB01069 Promethazine Thumb 21.9%
10 Approved;
SmallMoleculeDrug DB05381 Histamine Thumb 21.8%
11 Investigational SmallMoleculeDrug DB05885 Seletracetam Thumb 21.4%
12 Approved SmallMoleculeDrug DB00201 Caffeine Thumb 21.1%
13 Approved;
SmallMoleculeDrug DB01169 Arsenic trioxide Thumb 21.0%
14 Approved;
SmallMoleculeDrug DB00622 Nicardipine Thumb 20.5%
15 Experimental SmallMoleculeDrug DB03693 N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide Thumb 20.4%
16 Approved;
SmallMoleculeDrug DB09221 Polaprezinc Thumb 20.4%
17 Approved;
SmallMoleculeDrug DB09130 Copper Thumb 20.0%
18 Experimental SmallMoleculeDrug DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Thumb 19.7%
19 Investigational SmallMoleculeDrug DB05209 SYM001 Thumb 19.2%
20 Approved;
SmallMoleculeDrug DB04786 Suramin Thumb 19.1%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.