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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q15788
No. Gene UniProt ID Protein Name Pathway PDB
1 NCOA1 Q15788 Nuclear receptor coactivator 1 hsa04915; hsa04919; hsa05200; hsa05224


21 known interactions (drugs) of input target (NCOA1): Nuclear receptor coactivator 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB07215 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID Thumb
2 Investigational SmallMoleculeDrug DB08915 Aleglitazar Thumb
3 Experimental SmallMoleculeDrug DB06832 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL Thumb
4 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb
5 Experimental SmallMoleculeDrug DB08220 (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Thumb
6 Experimental SmallMoleculeDrug DB06875 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE Thumb
7 Investigational SmallMoleculeDrug DB01645 Genistein Thumb
8 Experimental SmallMoleculeDrug DB07236 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL Thumb
9 Experimental SmallMoleculeDrug DB07119 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL Thumb
10 Experimental SmallMoleculeDrug DB07009 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL Thumb
11 Experimental SmallMoleculeDrug DB07150 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME Thumb
12 Experimental SmallMoleculeDrug DB07230 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE Thumb
13 Experimental SmallMoleculeDrug DB04652 Corticosterone Thumb
14 Experimental SmallMoleculeDrug DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE Thumb
15 Experimental SmallMoleculeDrug DB06908 (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID Thumb
16 Experimental SmallMoleculeDrug DB08742 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Thumb
17 Experimental SmallMoleculeDrug DB07080 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Thumb
18 Experimental SmallMoleculeDrug DB07198 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE Thumb
19 Experimental SmallMoleculeDrug DB07530 (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol Thumb
20 Experimental SmallMoleculeDrug DB07724 Indeglitazar Thumb
21 Experimental SmallMoleculeDrug DB07557 (5BETA)-PREGNANE-3,20-DIONE Thumb


20 predicted interactions (drugs) of input target (NCOA1): Nuclear receptor coactivator 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 44.7%
2 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 43.7%
3 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 42.9%
4 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 39.7%
5 Approved;
Investigational		 SmallMoleculeDrug DB01393 Bezafibrate Thumb 39.6%
6 Experimental SmallMoleculeDrug DB04020 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol Thumb 38.0%
7 Approved;
Investigational		 SmallMoleculeDrug DB00255 Diethylstilbestrol Thumb 37.7%
8 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 36.4%
9 Approved;
Investigational		 SmallMoleculeDrug DB00481 Raloxifene Thumb 34.8%
10 Experimental SmallMoleculeDrug DB13869 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol Thumb 34.7%
11 Approved SmallMoleculeDrug DB11605 Myrrh Thumb 34.5%
12 Experimental SmallMoleculeDrug DB03860 N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide Thumb 34.3%
13 Experimental SmallMoleculeDrug DB02757 Pyrazole Thumb 33.8%
14 Approved SmallMoleculeDrug DB01878 Benzophenone Thumb 33.1%
15 Approved;
Investigational		 SmallMoleculeDrug DB00583 L-Carnitine Thumb 32.6%
16 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 31.8%
17 Approved SmallMoleculeDrug DB09086 Eugenol Thumb 31.8%
18 Investigational SmallMoleculeDrug DB11674 Equol Thumb 31.7%
19 Experimental SmallMoleculeDrug DB02983 Para-Mercury-Benzenesulfonic Acid Thumb 31.7%
20 Investigational;
Withdrawn		 SmallMoleculeDrug DB00197 Troglitazone Thumb 31.7%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.