QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O43923
No. Gene UniProt ID Protein Name Pathway PDB
1 mmp20 O43923 Matrix metalloproteinase-25 NA NA


2 known interactions (drugs) of input target (mmp20): Matrix metalloproteinase-25
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB01039 Fenofibrate Thumb
2 Approved SmallMoleculeDrug DB13873 Fenofibric acid Thumb


20 predicted interactions (drugs) of input target (mmp20): Matrix metalloproteinase-25
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 34.7%
2 Approved;
Investigational		 SmallMoleculeDrug DB01393 Bezafibrate Thumb 29.0%
3 Investigational SmallMoleculeDrug DB05187 Elafibranor Thumb 27.2%
4 Investigational;
Withdrawn		 SmallMoleculeDrug DB00197 Troglitazone Thumb 25.4%
5 Approved SmallMoleculeDrug DB09006 Clinofibrate Thumb 24.4%
6 Approved;
Investigational		 SmallMoleculeDrug DB08604 Triclosan Thumb 24.0%
7 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 23.0%
8 Approved;
Investigational		 SmallMoleculeDrug DB00412 Rosiglitazone Thumb 22.7%
9 Approved SmallMoleculeDrug DB11605 Myrrh Thumb 22.2%
10 Investigational SmallMoleculeDrug DB06521 Ertiprotafib Thumb 21.8%
11 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 21.5%
12 Approved SmallMoleculeDrug DB00573 Fenoprofen Thumb 20.3%
13 Approved;
Investigational		 SmallMoleculeDrug DB01132 Pioglitazone Thumb 20.3%
14 Investigational SmallMoleculeDrug DB06533 Ragaglitazar Thumb 20.2%
15 Investigational SmallMoleculeDrug DB04971 Reglixane Thumb 19.9%
16 Experimental SmallMoleculeDrug DB07724 Indeglitazar Thumb 19.8%
17 Investigational SmallMoleculeDrug DB05416 GW-501516 Thumb 19.6%
18 Approved;
Investigational		 SmallMoleculeDrug DB03756 Doconexent Thumb 19.5%
19 Withdrawn SmallMoleculeDrug DB07931 Hexestrol Thumb 19.0%
20 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb 19.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.