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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P48544
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ5 P48544 G protein-activated inward rectifier potassium channel 4 hsa04713; hsa04723; hsa04726; hsa04728; hsa04915; hsa04921; hsa04925; hsa05032 NA

2 known interactions (drugs) of input target (KCNJ5): G protein-activated inward rectifier potassium channel 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB01016 Glyburide Thumb
2 Approved SmallMoleculeDrug DB00898 Ethanol Thumb

20 predicted interactions (drugs) of input target (KCNJ5): G protein-activated inward rectifier potassium channel 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Vet approved
SmallMoleculeDrug DB01154 Thiamylal Thumb 28.4%
2 Investigational SmallMoleculeDrug DB05740 RPI-78M Thumb 22.0%
3 Approved SmallMoleculeDrug DB00674 Galantamine Thumb 21.8%
4 Investigational;
SmallMoleculeDrug DB00171 ATP Thumb 20.8%
5 Approved;
SmallMoleculeDrug DB00845 Clofazimine Thumb 20.3%
6 Approved SmallMoleculeDrug DB00184 Nicotine Thumb 20.3%
7 Approved;
Vet approved
SmallMoleculeDrug DB01159 Halothane Thumb 20.2%
8 Investigational SmallMoleculeDrug DB05137 Lobeline Thumb 19.0%
9 Approved;
Vet approved
SmallMoleculeDrug DB01028 Methoxyflurane Thumb 19.0%
10 Approved;
SmallMoleculeDrug DB11633 Isavuconazole Thumb 18.9%
11 Approved;
SmallMoleculeDrug DB01251 Gliquidone Thumb 18.8%
12 Approved;
Vet approved
SmallMoleculeDrug DB00794 Primidone Thumb 18.7%
13 Approved;
Vet approved
SmallMoleculeDrug DB00753 Isoflurane Thumb 18.5%
14 Approved;
SmallMoleculeDrug DB00237 Butabarbital Thumb 18.1%
15 Approved SmallMoleculeDrug DB01205 Flumazenil Thumb 17.7%
16 Approved;
SmallMoleculeDrug DB00747 Scopolamine Thumb 17.6%
17 Approved;
SmallMoleculeDrug DB01107 Methyprylon Thumb 17.4%
18 Approved;
SmallMoleculeDrug DB01273 Varenicline Thumb 17.0%
19 Approved;
Vet approved
SmallMoleculeDrug DB00312 Pentobarbital Thumb 16.9%
20 Approved SmallMoleculeDrug DB00222 Glimepiride Thumb 16.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.