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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35462
No. Gene UniProt ID Protein Name Pathway PDB
1 DRD3 P35462 D(3) dopamine receptor hsa04080; hsa04728 3PBL


50 known interactions (drugs) of input target (DRD3): D(3) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB12061 Pardoprunox Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
5 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
6 Investigational SmallMoleculeDrug DB05766 ACP-104 Thumb
7 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
8 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
9 Approved SmallMoleculeDrug DB11275 Epicriptine Thumb
10 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
11 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
12 Approved SmallMoleculeDrug DB01100 Pimozide Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB09289 Tianeptine Thumb
14 Experimental SmallMoleculeDrug DB09207 AS-8112 Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB06016 Cariprazine Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
17 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
19 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
20 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb
21 Investigational SmallMoleculeDrug DB12478 Piribedil Thumb
22 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01184 Domperidone Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
24 Approved SmallMoleculeDrug DB01235 Levodopa Thumb
25 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
26 Approved SmallMoleculeDrug DB11274 Dihydro-alpha-ergocryptine Thumb
27 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB09223 Blonanserin Thumb
29 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb
30 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb
31 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
33 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
35 Investigational SmallMoleculeDrug DB06477 Sumanirole Thumb
36 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
37 Investigational SmallMoleculeDrug DB06454 Sarizotan Thumb
38 Approved;
Investigational		 SmallMoleculeDrug DB06288 Amisulpride Thumb
39 Approved;
Withdrawn		 SmallMoleculeDrug DB00409 Remoxipride Thumb
40 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
42 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
43 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
44 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
45 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
47 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
48 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
49 Approved;
Investigational		 SmallMoleculeDrug DB00391 Sulpiride Thumb
50 Approved;
Investigational		 SmallMoleculeDrug DB09014 Captodiame Thumb


20 predicted interactions (drugs) of input target (DRD3): D(3) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 86.7%
2 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 86.5%
3 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 85.5%
4 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 83.5%
5 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 82.7%
6 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 82.5%
7 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb 82.2%
8 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb 81.4%
9 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 81.3%
10 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 80.9%
11 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 80.6%
12 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 80.1%
13 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb 79.9%
14 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb 79.4%
15 Withdrawn SmallMoleculeDrug DB00372 Thiethylperazine Thumb 79.4%
16 Approved;
Investigational		 SmallMoleculeDrug DB09097 Quinagolide Thumb 79.1%
17 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb 79.0%
18 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb 78.9%
19 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 78.8%
20 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 78.6%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.