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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P00439
No. Gene UniProt ID Protein Name Pathway PDB
1 PAH P00439 Phenylalanine-4-hydroxylase hsa00360; hsa00400; hsa00790; hsa01100; hsa01230 1DMW; 1J8T; 1J8U; 1KW0; 1LRM; 1MMK; 1MMT; 1PAH; 1TDW; 1TG2; 2PAH; 3PAH; 4ANP; 4PAH; 5PAH; 6PAH

9 known interactions (drugs) of input target (PAH): Phenylalanine-4-hydroxylase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB04419 D-norleucine Thumb
2 Approved;
Vet approved
SmallMoleculeDrug DB00668 Epinephrine Thumb
3 Approved;
SmallMoleculeDrug DB00120 L-Phenylalanine Thumb
4 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
5 Experimental SmallMoleculeDrug DB04400 L-erythro-7,8-dihydrobiopterin Thumb
6 Experimental SmallMoleculeDrug DB02562 Quinonoid 7,8-Tetrahydrobiopterin Thumb
7 Approved;
SmallMoleculeDrug DB00360 Sapropterin Thumb
8 Approved;
SmallMoleculeDrug DB06262 Droxidopa Thumb
9 Experimental SmallMoleculeDrug DB03673 Beta(2-Thienyl)Alanine Thumb

20 predicted interactions (drugs) of input target (PAH): Phenylalanine-4-hydroxylase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 44.8%
2 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb 36.5%
3 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 36.2%
4 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb 34.2%
5 Approved;
SmallMoleculeDrug DB01064 Isoprenaline Thumb 33.9%
6 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb 33.6%
7 Approved;
SmallMoleculeDrug DB00935 Oxymetazoline Thumb 33.5%
8 Approved;
SmallMoleculeDrug DB01363 Ephedra Thumb 33.3%
9 Approved;
SmallMoleculeDrug DB00182 Amphetamine Thumb 32.8%
10 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb 32.8%
11 Approved;
SmallMoleculeDrug DB06694 Xylometazoline Thumb 32.4%
12 Investigational SmallMoleculeDrug DB05461 OPC-28326 Thumb 32.1%
13 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 31.8%
14 Approved SmallMoleculeDrug DB00457 Prazosin Thumb 31.5%
15 Approved;
SmallMoleculeDrug DB09229 Aranidipine Thumb 31.1%
16 Approved;
SmallMoleculeDrug DB04846 Celiprolol Thumb 30.9%
17 Approved SmallMoleculeDrug DB01295 Bevantolol Thumb 30.7%
18 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb 30.5%
19 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 30.1%
20 Investigational SmallMoleculeDrug DB09204 Arotinolol Thumb 30.0%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.