QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9HBA0
No. Gene UniProt ID Protein Name Pathway PDB
1 TRPV4 Q9HBA0 Transient receptor potential cation channel subfamily V member 4 hsa04218; hsa04750; hsa05418 4DX1; 4DX2


3 known interactions (drugs) of input target (TRPV4): Transient receptor potential cation channel subfamily V member 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
2 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb


20 predicted interactions (drugs) of input target (TRPV4): Transient receptor potential cation channel subfamily V member 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb 49.6%
2 Approved SmallMoleculeDrug DB01744 Camphor Thumb 38.6%
3 Experimental SmallMoleculeDrug DB11345 (S)-camphor Thumb 35.2%
4 Investigational SmallMoleculeDrug DB14050 Cannabidivarin Thumb 31.3%
5 Experimental SmallMoleculeDrug DB02955 Ricinoleic Acid Thumb 30.7%
6 Approved SmallMoleculeDrug DB00825 Menthol Thumb 29.9%
7 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 27.2%
8 Approved;
Investigational		 SmallMoleculeDrug DB09288 Propacetamol Thumb 26.8%
9 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 23.2%
10 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 21.0%
11 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb 20.9%
12 Approved;
Investigational		 SmallMoleculeDrug DB06155 Rimonabant Thumb 20.8%
13 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 20.8%
14 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 20.0%
15 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb 19.5%
16 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 19.3%
17 Investigational SmallMoleculeDrug DB05509 LI-301 Thumb 19.0%
18 Approved;
Illicit		 SmallMoleculeDrug DB00470 Dronabinol Thumb 18.9%
19 Approved;
Investigational		 SmallMoleculeDrug DB00486 Nabilone Thumb 18.5%
20 Experimental SmallMoleculeDrug DB04444 Tetrafluoroaluminate Ion Thumb 18.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.